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Tubastatin A hydrochloride

SIGMA/SML0044 - ≥98% (HPLC)

Synonym: N-Hydroxy-4-(2-methyl-1,2,3,4-tetrahydro-pyrido[4,3-b]indol-5-ylmethyl)benzamide hydrochloried; N-Hydroxy-4-((2-methyl-3,4-dihydro-1H-pyrido[4,3-b]-indol-5(2H)-yl)methyl)benzamide hydrochloride

CAS Number: 1310693-92-5
Empirical Formula (Hill Notation): C20H21N3O2·HCl
Molecular Weight: 371.86
MDL Number: MFCD20488052
Linear Formula: C20H21N3O2·HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0044-5MG 5 mg
 $232.00
1/EA		 Add To Favorites
45-SML0044-25MG 25 mg
 $887.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML0044-25MG.

 

assay ≥98% (HPLC)
color white to tan
form powder
InChI 1S/C20H21N3O2.ClH/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25;/h2-9,25H,10-13H2,1H3,(H,21,24);1H
InChI key LJTSJTWIMOGKRJ-UHFFFAOYSA-N
Quality Level 100 
shipped in wet ice
SMILES string O=C(NO)C1=CC=C(CN2C3=C(C=CC=C3)C4=C2CCN(C)C4)C=C1.Cl
solubility DMSO: ≥10 mg/mL
storage condition desiccated
storage temp. −20°C
Application: Tubastatin A hydrochloride may be used in HDAC6-mediated cell signaling studies.
Biochem/physiol Actions: Tubastatin A Hydrochloride is a very selective HDAC6 inhibitor.
Biochem/physiol Actions: Tubastatin A increases the total numbers of mitochondria and restores the number of moving mitochondria in DRG neurons. It reverses the axonal loss in peripheral neurons in mouse model of Charcot-Marie-Tooth disease. Tubastatin A inhibits the deacetylation of α-tubulin in murine myoblasts.
Biochem/physiol Actions: Tubastatin A is a very selective HDAC6 inhibitor with an IC50 of 4 nM and 100 to over 1000-fold selectivity for HDAC6 over other HDAC classes.
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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