Synonym: N-Hydroxy-4-(2-methyl-1,2,3,4-tetrahydro-pyrido[4,3-b]indol-5-ylmethyl)benzamide hydrochloried; N-Hydroxy-4-((2-methyl-3,4-dihydro-1H-pyrido[4,3-b]-indol-5(2H)-yl)methyl)benzamide hydrochloride
CAS Number: 1310693-92-5
Empirical Formula (Hill Notation): C20H21N3O2·HCl
Molecular Weight: 371.86
MDL Number: MFCD20488052
Linear Formula: C20H21N3O2·HCl
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to tan |
| form |
powder |
| InChI |
1S/C20H21N3O2.ClH/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25;/h2-9,25H,10-13H2,1H3,(H,21,24);1H |
| InChI key |
LJTSJTWIMOGKRJ-UHFFFAOYSA-N |
| Quality Level |
100  |
| shipped in |
wet ice |
| SMILES string |
O=C(NO)C1=CC=C(CN2C3=C(C=CC=C3)C4=C2CCN(C)C4)C=C1.Cl |
| solubility |
DMSO: ≥10 mg/mL |
| storage condition |
desiccated |
| storage temp. |
−20°C |
| Application: |
Tubastatin A hydrochloride may be used in HDAC6-mediated cell signaling studies. |
| Biochem/physiol Actions: |
Tubastatin A Hydrochloride is a very selective HDAC6 inhibitor. |
| Biochem/physiol Actions: |
Tubastatin A increases the total numbers of mitochondria and restores the number of moving mitochondria in DRG neurons. It reverses the axonal loss in peripheral neurons in mouse model of Charcot-Marie-Tooth disease. Tubastatin A inhibits the deacetylation of α-tubulin in murine myoblasts. |
| Biochem/physiol Actions: |
Tubastatin A is a very selective HDAC6 inhibitor with an IC50 of 4 nM and 100 to over 1000-fold selectivity for HDAC6 over other HDAC classes. |
| Features and Benefits: |
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Packaging: |
5, 25 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
12352200 |
