MoTP
SIGMA/SML0047 - ≥98% (HPLC)
Synonym: 33N14; 4-
CAS Number: 57055-82-0
Empirical Formula (Hill Notation): C14H21NO2S
Molecular Weight: 267.39
MDL Number: MFCD00642470
Linear Formula: C14H21NO2S
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to tan |
| form | powder |
| InChI | 1S/C14H21NO2S/c16-13-3-5- |
| InChI key | YHKNLUTUXZDOQI-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | Oc1ccc(SCCCCN2CCOCC2)cc1 |
| solubility | DMSO: ≥80 mg/mL |
| storage temp. | −20°C |
| Application: | MoTP may be used in cell signaling and differentiation studies. |
| Biochem/physiol Actions: | Melanocytotoxic; reversibly blocks the specification of neural crest cells into melanocytes |
| Biochem/physiol Actions: | MoTP (also known as 33N14) reversibly blocks the specification of neural crest cells into melanocytes in zebrafish studies. Differentiation of neural crest cell-derived melanoblasts proceeds to late developmental stages, but they fail to reach the terminal stage of melanin production and die. Melanocytotoxicity is dependent on tyrosinase activity which convert it into a toxic form. MoTP specifically ablates only cells that express tyrosinase at high levels, which in the embryo are limited to melanoblasts and newly formed melanocytes. MoTP should be a useful tool for elucidating melanocyte stem cell regeneration, recruitment, and maintenance. |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |