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CP-101,606

SIGMA/SML0053 - ≥98% (HPLC)

Synonym: Traxoprodil; (1S,2S)-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol; CP-101606

CAS Number: 134234-12-1
Empirical Formula (Hill Notation): C20H25NO3
Molecular Weight: 327.42
MDL Number: MFCD00926469
Linear Formula: C20H25NO3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0053-5MG 5 mg
 $139.00
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45-SML0053-25MG 25 mg
 $580.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to tan
form powder
InChI 1S/C20H25NO3/c1-15(19(23)16-7-9-18(22)10-8-16)21-13-11-20(24,12-14-21)17-5-3-2-4-6-17/h2-10,15,19,22-24H,11-14H2,1H3/t15-,19+/m0/s1
InChI key QEMSVZNTSXPFJA-HNAYVOBHSA-N
optical activity [α]/D +50 to +60° (c=1, MeOH)
Quality Level 100 
SMILES string C[C@@H]([C@@H](O)c1ccc(O)cc1)N2CCC(O)(CC2)c3ccccc3
solubility DMSO: ≥35 mg/mL
storage temp. 2-8°C
Application: CP-101,606 has been used as a N-methyl-D-aspartate (NMDA) receptor antagonist to study its role in recovery of spinal cord injuries.
Biochem/physiol Actions: CP-101,606 (Traxoprodil) plays a role in inhibiting glutamate-induced death in rats. It may exhibit therapeutic effects against human ischemia and neurodegenerative disorders. Traxoprodil is metabolized by cytochrome P450 (CYP) 2D6.
Biochem/physiol Actions: Traxoprodil (CP-101,606) is a potent noncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptors, selective for the NR2B subunit. It has been shown to be neuroprotective in animal models of brain injury and stroke.
Biochem/physiol Actions: Traxoprodil (CP-101,606) is an NR2B selective NMDA antagonist
Features and Benefits: This compound is a featured product for Neuroscience research. Click here  to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the Glutamate Receptors (Ion Channel Family)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
General description: CP-101,606 (Traxoprodil) is a substituted 4-phenylpiperidine and is localized in the fore brain neurons.
Packaging: 5, 25 mg in glass bottle
Hazard Codes T,N
Risk Statements 25-36-50
Safety Statements 26-45-61
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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