Securinine
SIGMA/SML0055 - ≥98% (HPLC)
CAS Number: 5610-40-2
Empirical Formula (Hill Notation): C13H15NO2
Molecular Weight: 217.26
MDL Number: MFCD00078775
Linear Formula: C13H15NO2
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | yellow |
| form | powder |
| InChI | 1S/C13H15NO2/c15-12-7-9-4 |
| InChI key | SWZMSZQQJRKFBP-WZRBSPASSA |
| optical activity | [α]/D -980 to -1015 (C=1, MeOH) |
| Quality Level | 100  |
| SMILES string | O=C1O[C@@]23C[C@@H](C=CC2 |
| solubility | DMSO: ≥25 mg/mL |
| storage temp. | 2-8°C |
| Application: | Securinine was used as a standard in the synthesis of the members of Securinega alkaloid family. |
| Biochem/physiol Actions: | Securinine is a GABAA receptor antagonist which has been found to increase p73 protein expression |
| Biochem/physiol Actions: | Securinine is an alkaloid widely in traditional folk medicine. Long known as a GABAA antagonist, securinine was recently found to up-regulate p53 protein and to modulate the related family member p73 protein in a p53-dependent fashion, inducing p73 in the HCT116 p53(-) cells and down-regulating it in the p53(+) cells. Induction of proapoptotic protein p73 only in p53 cells could be used to target cancer cells preferentially. Securinine has been found to induce p53-independent, p73-dependent apoptosis in RKO colon cancer cells. |
| Features and Benefits: | This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P264 - P270 - P301 + P310 - P405 - P501 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |