Synonym: (6R,7R)-7-[[2-(2-Amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]-thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride hydrate
CAS Number: 66309-69-1 (anhydrous)
Empirical Formula (Hill Notation): C18H23N9O4S3 · 2HCl · xH2O
Molecular Weight: 598.55 (anhydrous basis)
Linear Formula: C18H23N9O4S3 · 2HCl · xH2O
Product Type: Chemical
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| antibiotic activity spectrum |
Gram-negative bacteria |
| |
Gram-positive bacteria |
| assay |
≥98% (HPLC) |
| color |
white to tan |
| form |
powder |
| InChI |
1S/C18H23N9O4S3.2ClH/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14(29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10;;/h8,12,15H,3-7H2,1-2H3,(H2,19,20)(H,21,28)(H,30,31);2*1H/t12-,15-;;/m1../s1 |
| InChI key |
BWRRTAXZCKVRON-DGPOFWGLSA-N |
| mode of action |
cell wall synthesis | interferes |
| Quality Level |
100  |
| SMILES string |
[s]1c(nc(c1)CC(=O)N[C@H]2[C@H]3SCC(=C(N3C2=O)C(=O)O)CSc4[n](nnn4)CCN(C)C)N.[Cl-].[Cl-].[H+].[H+] |
| solubility |
H2O: ≥22 M |
| storage condition |
desiccated |
| storage temp. |
2-8°C |
| Application: |
Cefotiam dihydrochloride hydrate is used as broad-spectrum antibiotic. |
| Biochem/physiol Actions: |
Cefotiam is a second generation cephalosporin antibiotic which has been used as a prophylatic antibiotic for MRSA. |
| Biochem/physiol Actions: |
Cefotiam, a derivative of cephalosporin, exhibits broad-spectrum anti-bacterial activity. It inhibits the cross-linking stage of peptidoglycan and blocks the synthesis of bacterial cell wall. It is resistant to β-lactamases. |
| Biochem/physiol Actions: |
Second generation cephalosporin, prophylatic antibiotic for MRSA |
| General description: |
Chemical structure: ß-lactam |
| Packaging: |
10, 50 mg in glass bottle |
| Symbol |
GHS07 |
| Signal word |
Warning |
| Hazard statements |
H319 |
| Precautionary statements |
P305 + P351 + P338 |
| Hazard Codes |
Xi |
| Risk Statements |
36 |
| Safety Statements |
26 |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |