Cefotiam dihydrochloride hydrate
SIGMA/SML0056 - ≥98% (HPLC)
Synonym: (6R,7R)
CAS Number: 66309-69-1 (anhydrous)
Empirical Formula (Hill Notation): C18H23N9O4S3 · 2HCl · xH2O
Molecular Weight: 598.55 (anhydrous basis)
Linear Formula: C18H23N9O4S3 · 2HCl · xH2O
Product Type: Chemical
| antibiotic activity spectrum | Gram-negative bacteria |
| Gram-positive bacteria | |
| assay | ≥98% (HPLC) |
| color | white to tan |
| form | powder |
| InChI | 1S/C18H23N9O4S3.2ClH/c1-2 |
| InChI key | BWRRTAXZCKVRON-DGPOFWGLSA |
| mode of action | cell wall synthesis | interferes |
| Quality Level | 100 ![]() |
| SMILES string | [s]1c(nc(c1)CC(=O)N[C@H]2 |
| solubility | H2O: ≥22 M |
| storage condition | desiccated |
| storage temp. | 2-8°C |
| Application: | Cefotiam dihydrochloride hydrate is used as broad-spectrum antibiotic. |
| Biochem/physiol Actions: | Cefotiam is a second generation cephalosporin antibiotic which has been used as a prophylatic antibiotic for MRSA. |
| Biochem/physiol Actions: | Cefotiam, a derivative of cephalosporin, exhibits broad-spectrum anti-bacterial activity. It inhibits the cross-linking stage of peptidoglycan and blocks the synthesis of bacterial cell wall. It is resistant to β-lactamases. |
| Biochem/physiol Actions: | Second generation cephalosporin, prophylatic antibiotic for MRSA |
| General description: | Chemical structure: ß-lactam |
| Packaging: | 10, 50 mg in glass bottle |
| Symbol | GHS07 |
| Signal word | Warning |
| Hazard statements | H319 |
| Precautionary statements | P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Statements | 36 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |


