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Camostat mesylate

SIGMA/SML0057 - ≥98% (HPLC)

Synonym: 4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic acid 2-(dimethylamino)-2-oxoethyl ester methanesulfonate; FOY 305; FOY-S 980; Foipan mesylate

CAS Number: 59721-29-8
Empirical Formula (Hill Notation): C20H22N4O5·CH3SO3H
Molecular Weight: 494.52
MDL Number: MFCD00941410
Linear Formula: C20H22N4O5·CH3SO3H
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0057-10MG 10 mg
 $75.20
1/EA		 Add To Favorites
45-SML0057-50MG 50 mg
 $286.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to tan
form powder
InChI 1S/C20H22N4O5.CH4O3S/c1-24(2)17(25)12-28-18(26)11-13-3-9-16(10-4-13)29-19(27)14-5-7-15(8-6-14)23-20(21)22;1-5(2,3)4/h3-10H,11-12H2,1-2H3,(H4,21,22,23);1H3,(H,2,3,4)
InChI key FSEKIHNIDBATFG-UHFFFAOYSA-N
originator Novartis
Quality Level 100 
SMILES string CS(O)(=O)=O.CN(C)C(=O)COC(=O)Cc1ccc(OC(=O)c2ccc(NC(N)=N)cc2)cc1
solubility H2O: ≥24 mg/mL
storage temp. 2-8°C
Application: Camostat mesylate has been used to determine the effect of transmembrane protease, serine (TMPRSS) family proteases on cell-cell fusion.
Application: Camostat mesylate may be used in cell signaling studies.
Biochem/physiol Actions: Camostat is a serine protease inhibitor, airway epithelial sodium channel (ENaC) attenuator.
Biochem/physiol Actions: Camostat is a synthetic, orally bioavailble serine protease inhibitor and airway epithelial sodium channel (ENaC) attenuator.
Biochem/physiol Actions: Camostat mesylate (CM) is used to treat pancreatitis and reflux esophagitis after gastrectomy.
Biochem/physiol Actions: Camostat mesylate inhibits the production of TNF-α and monocyte chemoattractant protein-1 (MCP-1) by monocytes. It also inhibits the activity of pancreatic stellate cells. Camostat mesylate regulates the cytokine expression and inflammation and is effective in the treatment of dibutyltin dichloride-induced rat pancreatic fibrosis.
Features and Benefits: This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits: This compound was developed by Novartis . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 10, 50 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352203

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