BLT-1
SIGMA/SML0059 - ≥98% (HPLC)
Synonym: 2-
CAS Number: 321673-30-7
Empirical Formula (Hill Notation): C12H23N3S
Molecular Weight: 241.40
MDL Number: MFCD00571007
Linear Formula: C12H23N3S
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to tan |
| form | powder |
| InChI | 1S/C12H23N3S/c1-2-3-4-5-7 |
| InChI key | OWGUSBISUVLUJF-SDNWHVSQSA |
| Quality Level | 100  |
| SMILES string | CCCCCCC1CCCC1=N/NC(N)=S |
| solubility | DMSO: ≥13 mg/mL |
| storage temp. | 2-8°C |
| Application: | BLT-1 (Block lipid transport-1) has been used as an inhibitor of the SR-BI (scavenger receptor, class B, type I) mediated lipid transfer to determine if miR-223-3p export from polymorphonuclear neutrophils (PMNs) to high-density lipoproteins (HDLs) is dependent on SR-BI-mediated lipid flux. It has also been used as a SR-BI inhibitor to study the effect of HDL on osteocalcin (OCN) expression in monocyte cell lines through SR-B1. |
| Application: | BLT-1 may be used to study cell signaling pathways that have role in cholesterol influx and efflux. |
| Biochem/physiol Actions: | Block lipid transport-1 (BLT-1) is a specific inhibitor of the SR-BI (Scavenger receptor, class B, type I) mediated lipid transfer. The compound inhibits both cellular selective lipid uptake of HDL cholesteryl ether and efflux of cellular cholesterol to HDL. |
| Biochem/physiol Actions: | Specific inhibitor of the SR-BI (Scavenger receptor, class B, type I) mediated lipid transfer |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 51111800 |