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SAHA

SIGMA/SML0061 - ≥98% (HPLC)

Synonym: N-hydroxy-N′-phenyl-octanediamide; Suberoylanilide hydroxamic acid; Vorinostat

CAS Number: 149647-78-9
Empirical Formula (Hill Notation): C14H20N2O3
Molecular Weight: 264.32
MDL Number: MFCD00945317
Linear Formula: C14H20N2O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0061-5MG 5 mg
 $105.00
1/EA		 Add To Favorites
45-SML0061-25MG 25 mg
 $429.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to tan
form powder
InChI 1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
InChI key WAEXFXRVDQXREF-UHFFFAOYSA-N
Quality Level 100 
shipped in wet ice
SMILES string ONC(=O)CCCCCCC(=O)Nc1ccccc1
solubility DMSO: ≥15 mg/mL
storage temp. −20°C
Application: SAHA may be used to study gene regulation, transcription regulation and cell signaling.
Biochem/physiol Actions: Potent, reversible pan-histone deacetylase (HDAC) inhibitor.
Biochem/physiol Actions: SAHA or Vorinostat facilitates the transcription of genes that result in apoptosis, differentiation and growth arrest. It has been observed to give beneficial results in lymphoma but not in solid tumors.
Biochem/physiol Actions: Vorinostat or suberoylanilide hydroxamic acid (SAHA) is a potent, reversible pan-histone deacetylase (HDAC) inhibitor. It inhibits both class I and class II HDACs, altering gene transcription and inducing cell cycle arrest and/or apoptosis in a wide variety of transformed cells.
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 5, 25 mg in glass bottle
Symbol GHS08  GHS08
Signal word Danger
Hazard statements H341 - H360
Precautionary statements P201 - P308 + P313
Hazard Codes T
Risk Statements 61-68
Safety Statements 53-36/37-45
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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