Q-VD-OPh hydrate

SIGMA/SML0063 - ≥95% (HPLC)

Synonym: 5-(2,6-Difluorophenoxy)-3-[[3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-pentanoic acid hydrate

CAS Number: 1435786-01-8
Empirical Formula (Hill Notation): C₂₆H₂₅F₂N₃O₆ · xH₂O
Molecular Weight: 513.49 (anhydrous basis)
Linear Formula: C₂₆H₂₅F₂N₃O₆ · xH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0063-1MG	1 mg	$285.00 1/EA	Add To Favorites
45-SML0063-5MG	5 mg	$1140.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: SML0063-1MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95% (HPLC)
color	white to light brown
form	powder
InChI	1S/C26H25F2N3O6.H2O/c1-14(2)23(31-25(35)19-11-10-15-6-3-4-9-18(15)29-19)26(36)30-20(12-22(33)34)21(32)13-37-24-16(27)7-5-8-17(24)28;/h3-11,14,20,23H,12-13H2,1-2H3,(H,30,36)(H,31,35)(H,33,34);1H2/t20-,23-;/m0./s1
InChI key	ONOTWLLTFZMERH-WCRWPNQISA-N
shipped in	wet ice
SMILES string	O=C(NC(C(C)C)C(NC(C(COC1=C(F)C=CC=C1F)=O)CC(O)=O)=O)C2=NC3=CC=CC=C3C=C2.[H]O[H]
solubility	DMSO: ≥14 mg/mL
storage condition	desiccated
storage temp.	−20°C

Application:	Q-VD-OPh hydrate has been used: • as a pan-caspase inhibitor to prevent cell death in urothelial carcinoma cells (UCC) • to induce canonical caspase-dependent apoptosis in UC cells • to block caspase-3 and Poly (ADP-ribose) polymerase-1 (PARP-1) • to study the protective role of EspZ effector protein against apoptosis and necrosis in human epithelial cells
Biochem/physiol Actions:	Pan-caspase inhibitor.
Biochem/physiol Actions:	Q-VD-OPh is a potent pan-caspase inhibitor that protects cells from capsase-dependent apoptosis. Q-VD-OPh has superior aqueous stability, cell permeability, and efficacy than FMK-based caspase inhibitors and displays no cytotoxic effects alone.
Features and Benefits:	This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	1, 5 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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