MBX-102
SIGMA/SML0064 - ≥98% (HPLC)
Synonym: (aR)
CAS Number: 24136-23-0
Empirical Formula (Hill Notation): C19H17ClF3NO4
Molecular Weight: 415.79
Linear Formula: C19H17ClF3NO4
Product Type: Chemical
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| assay | ≥98% (HPLC) |
| color | white to tan |
| form | powder |
| InChI | 1S/C19H17ClF3NO4/c1-12(25 |
| InChI key | BJBCSGQLZQGGIQ-QGZVFWFLSA |
| originator | Johnson & Johnson |
| Quality Level | 100  |
| SMILES string | FC(F)(F)c1cc(ccc1)O[C@H]( |
| solubility | DMSO: ≥35 mg/mL |
| storage temp. | 2-8°C |
| Application: | MBX-102 may be used in PPAR-mediated cell signaling studies. |
| Biochem/physiol Actions: | MBX-102 has a potent transrepression effect on PPARγ. It is an oral glucose-reducing agent and also has insulin-sensitizing properties. It is useful as treatment for type 2 diabetes. MBX-102 also lowers triglycerides in a PPARα-independent manner. |
| Biochem/physiol Actions: | MBX-102 is a selective PPAR modulator (SPPARM) and has been shown to inhibit phosphorylation of PPARγ. MBX-102 is converted to the active form, MBX-102 acid, in vivo. |
| Biochem/physiol Actions: | Selective PPAR modulator (SPPARM). |
| Features and Benefits: | This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Features and Benefits: | This compound is featured on the Nuclear Receptors (Non-Steroids) and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Features and Benefits: | This compound was developed by Johnson & Johnson . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |   GHS06,GHS09 |
| Signal word | Danger |
| Hazard statements | H301 - H319 - H400 |
| Precautionary statements | P273 - P301 + P310 + P330 - P305 + P351 + P338 |
| Hazard Codes | T,N |
| Risk Statements | 25-36-50/53 |
| Safety Statements | 26-45-60-61 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |