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NGB 2904 hydrochloride

SIGMA/SML0066 - ≥98% (HPLC)

Synonym: N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide hydrochloride

CAS Number: 189061-11-8
Empirical Formula (Hill Notation): C28H29Cl2N3O·HCl
Molecular Weight: 530.92
MDL Number: MFCD09971107
Linear Formula: C28H29Cl2N3O·HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0066-5MG 5 mg
 $143.00
1/EA		 Add To Favorites
45-SML0066-25MG 25 mg
 $551.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to tan
form powder
InChI 1S/C28H29Cl2N3O.ClH/c29-25-8-5-9-26(27(25)30)33-16-14-32(15-17-33)13-4-3-12-31-28(34)21-10-11-24-22(19-21)18-20-6-1-2-7-23(20)24;/h1-2,5-11,19H,3-4,12-18H2,(H,31,34);1H
InChI key PFIWYJNBKGCVFM-UHFFFAOYSA-N
Quality Level 100 
SMILES string Cl.Clc1cccc(N2CCN(CCCCNC(=O)c3ccc-4c(Cc5ccccc-45)c3)CC2)c1Cl
solubility DMSO: ≥25 mg/mL
storage condition desiccated
storage temp. 2-8°C
Application: NGB 2904 hydrochloride may be used in cell signaling studies.
Biochem/physiol Actions: Inhibition of dopamine D3 receptor function by NGB 2904 increases spontaneous locomotor activity in rodents.
Biochem/physiol Actions: NGB 2904 hydrochloride is a potent and selective dopamine D3 receptor antagonist
Biochem/physiol Actions: NGB 2904 is a potent and selective dopamine D3 receptor antagonist with a D3/D2 ratio of 800 for rat and high binding affinity (1.4 nM) at the hD3 receptor with 150-fold selectivity for primate D3 receptors over primate D2L receptors. It attenuates the rewarding effects of cocaine and methamphetamine.
Features and Benefits: This compound is featured on the Dopamine Receptors  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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