IOX1

SIGMA/SML0067 - ≥97% (HPLC)

Synonym: 5-Carboxy-8-hydroxyquinoline; 8-Hydroxy-5-quinolinecarboxylic acid

CAS Number: 5852-78-8
Empirical Formula (Hill Notation): C₁₀H₇NO₃
Molecular Weight: 189.17
MDL Number: MFCD18417145
Linear Formula: C₁₀H₇NO₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML0067-5MG	5 mg	$145.00 1/EA		Add To Favorites
45-SML0067-25MG	25 mg	$551.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥97% (HPLC)
color	white to brown
form	powder
InChI	1S/C10H7NO3/c12-8-4-3-7(10(13)14)6-2-1-5-11-9(6)8/h1-5,12H,(H,13,14)
InChI key	JGRPKOGHYBAVMW-UHFFFAOYSA-N
SMILES string	OC(=O)c1ccc(O)c2ncccc12
solubility	DMSO: 10 mg/mL, clear
storage temp.	2-8°C

Application:	IOX1 has been used: • To eliminate viral latency in latent viruses in order to sensitize the viral infections to antiviral therapy. • In histone lysine demethylase 4A (KDM4A) inhibition, to serve as a unique strategy to decrease hypoxia-inducible factors signalling. • to restore oncogene-induced senescence in wild-type mouse embryo fibroblasts.
Biochem/physiol Actions:	Broad spectrum 2-oxoglutarate (2OG) oxygenase inhibitor.
Biochem/physiol Actions:	IOX1 (5-Carboxy-8-hydroxyquinoline) is a broad spectrum inhibitor of 2-oxoglutarate (2OG) oxygenases, including Jumonji C domain (JmjC) demethylases. It is useful for the study of histone demethylation and hypoxic sensing and results in translocation of active site iron on the 2OG oxygenases. For full characterization details, please visit the IOX1 probe summary on the Structural Genomics Consortium (SGC) website. To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
Biochem/physiol Actions:	IOX1 has an IC50 value as 200nM. IOX1 might be used in the treatment of β-thalassemia by α-globin downregulation.
Features and Benefits:	IOX1 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC .
Features and Benefits:	This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging:	5, 25 mg in glass bottle

Hazard Codes	Xn
Risk Statements	22
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97% (HPLC)
Storage Temp.	2-8°C
UNSPSC	51111800

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