Acenocoumarol
SIGMA/SML0074 - ≥98% (HPLC)
Synonym: (±)-Acenocoumarin; 3-(α-Acetonyl-p-nitrobenzyl)-4-hydroxy-coumarin
CAS Number: 152-72-7
Empirical Formula (Hill Notation): C19H15NO6
Molecular Weight: 353.33
EC Number: 205-807-3
MDL Number: MFCD00137816
Linear Formula: C19H15NO6
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to tan |
| form | powder |
| InChI | 1S/C19H15NO6/c1-11(21)10- |
| InChI key | VABCILAOYCMVPS-UHFFFAOYSA |
| originator | Novartis |
| Quality Level | 100  |
| SMILES string | CC(=O)CC(c1ccc(cc1)[N+]([ |
| solubility | DMSO, heptane and xylene: ≥17 mg/mL |
| storage temp. | −20°C |
| Application: | Acenocoumarol has been used as a standard for the determination of coumarins in cosmetics. |
| Application: | Acenocoumarol was used to study the role of P-glycoprotein in transport of oral vitamin K in Caco-2 cells and as an LC/MS standard. |
| Biochem/physiol Actions: | Acenocoumarol is a warfarin analog, an anticoagulant that inhibits Vitamin K epoxide reductase. This results in depletion of the reduced form of vitamin K (vitamin KH2), limiting the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S, resulting in decreased prothrombin levels and the amount of thrombin generated. |
| Biochem/physiol Actions: | Acenocoumarol is effective against thromboembolic disorders. |
| Features and Benefits: | This compound was developed by Novartis . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| Packaging: | 10, 50 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 - H315 - H319 - H335 |
| Precautionary statements | P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | Xn |
| Risk Statements | 63-22-36/37/38 |
| Safety Statements | 26-36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |