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Zoniporide hydrochloride hydrate

SIGMA/SML0076 - ≥98% (HPLC)

Synonym: N-(Aminoiminomethyl)-5-cyclopropyl-1-(5-quinolinyl)-1H-pyrazole-4-carboxamide hydrochloride hydrate

CAS Number: 241800-98-6 (free base)
Empirical Formula (Hill Notation): C17H16N6O · xHCl · yH2O
Molecular Weight: 320.35 (anhydrous free base basis)
MDL Number: MFCD04113213
Linear Formula: C17H16N6O · xHCl · yH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0076-10MG 10 mg
 $279.00
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45-SML0076-50MG 50 mg
 $1060.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to tan
form powder
InChI 1S/C17H16N6O.ClH.H2O/c18-17(19)22-16(24)12-9-21-23(15(12)10-6-7-10)14-5-1-4-13-11(14)3-2-8-20-13;;/h1-5,8-10H,6-7H2,(H4,18,19,22,24);1H;1H2
InChI key UCIJUEGJEFJRMP-UHFFFAOYSA-N
Quality Level 100 
SMILES string O.Cl.NC(=N)NC(=O)c1cnn(-c2cccc3ncccc23)c1C4CC4
solubility H2O: 2 mg/mL, clear (warmed)
storage condition desiccated
storage temp. 2-8°C
Application: Zoniporide hydrochloride hydrate has been used for the inhibition of sodium-hydrogen exchanger isoform 1 (NHE-1) in rat models. It has also been used in cytotoxicity assay and to study its effect on lymphocytic choriomeningitis virus multiplication.
Application: Zoniporide hydrochloride hydrate may be used in Na+/H+-mediated cell signaling studies.
Biochem/physiol Actions: Potent and selective inhibitor of Na+/H+ exchanger isoform 1 (NHE-1)
Biochem/physiol Actions: Zoniporide is a potent and selective inhibitor of Na+/H+ exchanger isoform 1 (NHE-1). IC50 = 59 nM at NHE-1, vs. 12,000 nM at NHE-2; Zoniporide inhibits NHE-1-dependent Na+ update with IC50 of 14 nM.
Biochem/physiol Actions: Zoniporide, a selective inhibitor of sodium-hydrogen exchanger isoform 1 (NHE-1) has cardioprotective effects against myocardial injuries and ischemic insults. It inhibits the swelling human platelets and attenuates cardiac contractile dysfunction in rats. Zoniporide might have neurotoxic effects as it causes peripheral sensory axonopathy.
Packaging: 10, 50 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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