VU591

SIGMA/SML0077 - ≥98% (HPLC)

Synonym: 2,2′-(oxydimethanediyl)bis(5-nitro-1H-benzimidazole); 2,2′-(oxydimethanediyl)bis(6-nitro-1H-benzimidazole); 5-nitro-2-{[(6-nitro-1H-benzimidazol-2-yl)methoxy]methyl}-1H-benzimidazole

CAS Number: 1222810-74-3
Empirical Formula (Hill Notation): C₁₆H₁₂N₆O₅
Molecular Weight: 368.30
Linear Formula: C₁₆H₁₂N₆O₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0077-5MG	5 mg	$121.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to tan
form	powder
InChI	1S/C16H12N6O5/c23-21(24)9-1-3-11-13(5-9)19-15(17-11)7-27-8-16-18-12-4-2-10(22(25)26)6-14(12)20-16/h1-6H,7-8H2,(H,17,19)(H,18,20)
InChI key	ZQPXNYLXYNRFNP-UHFFFAOYSA-N
Quality Level	100
SMILES string	[O-][N+](=O)c1ccc2nc(COCc3nc4ccc(cc4[nH]3)[N+]([O-])=O)[nH]c2c1
solubility	DMSO: ≥12 mg/mL
storage temp.	2-8°C

Application:	VU591 may be used in cell signaling studies.
Biochem/physiol Actions:	ROMK (Kir 1.1) inhibitor
Biochem/physiol Actions:	VU591 is a Potassium Inwardly-Rectifying Channel (KCNJ1 or ROMK) specific inhibitor (IC50 = 240 nM) that is closely related to VU590. Unlike VU590, VU591 does not inhibit Kir7.1. The compound has a modest effect on Kir6.2/SUR1, causing 17% inhibition at 10 uM.
Features and Benefits:	This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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