VU591
SIGMA/SML0077 - ≥98% (HPLC)
Synonym: 2,2′-(oxydimethanediyl)bis(5-nitro-1H-benzimidazole); 2,2′-(oxydimethanediyl)bis(6-nitro-1H-benzimidazole); 5-
CAS Number: 1222810-74-3
Empirical Formula (Hill Notation): C16H12N6O5
Molecular Weight: 368.30
Linear Formula: C16H12N6O5
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to tan |
form | powder |
InChI | 1S/C16H12N6O5/c23-21(24)9 |
InChI key | ZQPXNYLXYNRFNP-UHFFFAOYSA |
Quality Level | 100 ![]() |
SMILES string | [O-][N+](=O)c1ccc2nc(COCc |
solubility | DMSO: ≥12 mg/mL |
storage temp. | 2-8°C |
Application: | VU591 may be used in cell signaling studies. |
Biochem/physiol Actions: | VU591 is a Potassium Inwardly-Rectifying Channel (KCNJ1 or ROMK) specific inhibitor (IC50 = 240 nM) that is closely related to VU590. Unlike VU590, VU591 does not inhibit Kir7.1. The compound has a modest effect on Kir6.2/SUR1, causing 17% inhibition at 10 uM. |
Features and Benefits: | This compound is featured on the Potassium Channels ![]() ![]() |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |