GSK 1059615 sodium salt hydrate

SIGMA/SML0083

Synonym: (5Z)-5-[[4-(4-pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidinedione sodium salt hydrate

Empirical Formula (Hill Notation): C₁₈H₁₀N₃O₂S·Na · xH₂O
Molecular Weight: 355.35 (anhydrous basis)
Linear Formula: C₁₈H₁₀N₃O₂S·Na · xH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0083-10MG	10 mg	$120.00 1/EA	Add To Favorites
45-SML0083-50MG	50 mg	$489.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

color	yellow
form	powder
InChI	1S/C18H11N3O2S.Na.H2O/c22-17-16(24-18(23)21-17)10-11-1-2-15-14(9-11)13(5-8-20-15)12-3-6-19-7-4-12;;/h1-10H,(H,21,22,23);;1H2/q;+1;/p-1/b16-10-;;
InChI key	KKSRFFGUIONCPS-FLPKAINGSA-M
originator	GlaxoSmithKline
Quality Level	100
SMILES string	O.[Na+].O=C1[N-]C(=O)C(S1)=Cc2ccc3nccc(-c4ccncc4)c3c2
solubility	H₂O: ≥8 mg/mL
storage temp.	2-8°C

Biochem/physiol Actions:	GSK 1059615 is a phosphatidylinositol-3-kinases (PI3K) inhibitor. GSK 1059615 inhibits proliferation of breast cancer BT474 cells via four different mechanisms that include retinoblastoma 1 (RB1)-mediated cell cycle arrest, elevated forkhead box protein O1 (FOXO) signaling, deduced MYC and transferrin receptor (TFRC) signaling and decreased cellular metabolism. Additionally, GSK 1059615 can suppress cell proliferation by decreasing mitogen-activated protein kinase (MAPK) signaling and imparts sensitivity to phosphoinositide 3-kinase (PI3K) inhibitor in cells resistant to the protein kinase B or AKT inhibitor. GSK 1059615 functions as a druggable target to reduce radiation-induced apoptosis in NCCIT cells. GSK 1059615 has entered clinical trial in patients with solid tumors or lymphoma and refractory malignancies.
Biochem/physiol Actions:	GSK 1059615 is a potent inhibitor of PI3 Kinase. (IC₅₀ = 2 nM)
Disclaimer:	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits:	This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	This compound was developed by GlaxoSmithKline . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging:	10, 50 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	12352203

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