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IM-12

SIGMA/SML0084 - ≥98% (HPLC)

Synonym: 3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione

CAS Number: 1129669-05-1
Empirical Formula (Hill Notation): C22H20FN3O2
Molecular Weight: 377.41
MDL Number: MFCD20527313
Linear Formula: C22H20FN3O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0084-5MG 5 mg
 $136.00
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assay ≥98% (HPLC)
color yellow-orange
form powder
InChI 1S/C22H20FN3O2/c1-13-18(16-5-3-4-6-17(16)25-13)19-20(22(28)26(2)21(19)27)24-12-11-14-7-9-15(23)10-8-14/h3-10,24-25H,11-12H2,1-2H3
InChI key ZKJAZFUFPPSFCO-UHFFFAOYSA-N
Quality Level 100 
SMILES string CN1C(=O)C(NCCc2ccc(F)cc2)=C(C1=O)c3c(C)[nH]c4ccccc34
solubility DMSO: ≥9 mg/mL
storage condition desiccated
storage temp. 2-8°C
Biochem/physiol Actions: IM-12 is a cell-permeable indolylmaleimide that acts as a Glycogen synthase kinase 3β (GSK-3β) inhibitor, activating downstream components of canonical Wnt signaling. IM-12 significantly increased β-catenin levels. When used to treat human neural progenitor cells, IM-12 promoted neuronal differentiation resulting in an increase of neuronal cells. It has an IC50 of 53 nM in an in vitro binding assay, compared with 92 nM for SB-216763 in the same assay condition.
Packaging: 5, 25 mg in glass bottle
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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