A-967079
SIGMA/SML0085 - ≥98% (HPLC)
Synonym: (1E,3E)
CAS Number: 1170613-55-4
Empirical Formula (Hill Notation): C12H14FNO
Molecular Weight: 207.24
MDL Number: MFCD20488058
Linear Formula: C12H14FNO
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to tan |
| form | powder |
| InChI | 1S/C12H14FNO/c1-3-12(14-1 |
| InChI key | HKROEBDHHKMNBZ-CHBKHGQFSA |
| originator | Abbott |
| Quality Level | 100  |
| SMILES string | CCC(=N/O)C(C)=Cc1ccc(F) |
| solubility | DMSO: ≥12 mg/mL |
| storage temp. | 2-8°C |
| Application: | A-967079 has been used in blocking miR-711-induced TRPA1 (transient receptor potential cation channel subfamily A member 1) channel. |
| Biochem/physiol Actions: | A-967079 is a potent and selective antagonist of Transient Receptor Potential Anykrin 1 (TRPA1) with IC50′s of 67 nM and 289 nM at human and rat TRPA1 receptors, respectively, and minimal or no activity at other TRP channels or G-protein-coupled receptors, enzymes, transporters, and ion channels out of 89 tested. A-967079 blocks TRPA1 activation in human and rat cell lines and has been shown to reduce the responses of wide dynamic range (WDR) and nociceptive specific (NS) neurons to high-intensity mechanical stimulation. |
| Biochem/physiol Actions: | TRPA1 receptor antagonist |
| Features and Benefits: | This compound was developed by Abbott . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| General description: | A-967079 prevents neuropathic and inflammatory pain. It reduces cold allodynia, which is produced by nerve injury. |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |