Abacavir sulfate
SIGMA/SML0089 - ≥98% (HPLC)
Synonym: (1S,4R)
CAS Number: 188062-50-2
Empirical Formula (Hill Notation): C14H18N6O · 0.5 H2SO4
Molecular Weight: 335.37
MDL Number: MFCD04112763
Linear Formula: C14H18N6O · 0.5 H2SO4
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to tan |
form | powder |
InChI | 1S/2C14H18N6O.H2O4S/c2*15 |
InChI key | WMHSRBZIJNQHKT-FFKFEZPRSA |
optical activity | [α]/D -30 to -40°, c = 0.5 in methanol |
originator | GlaxoSmithKline |
Quality Level | 100 ![]() |
SMILES string | OS(O)(=O)=O.Nc1nc(NC2CC2) |
solubility | H2O: ≥17 mg/mL |
storage temp. | 2-8°C |
Application: | Abacavir sulfate has been used as a compound to validate the P19C5 gastrulation in mouse. It has also been used to induces chromosomal double-strand breaks (DSBs) and kills adult T cell leukemia (ATL) cells. |
Application: | Abacavir sulfate has been used in the cytotoxicity to test its tumour promoting activity U937 cells. |
Biochem/physiol Actions: | Abacavir incorporated in the cells is converted to triphosphate containing guanine analog carbovir (CBV) and it favors the generation of higher double stranded breaks (DSBs). |
Biochem/physiol Actions: | Abacavir sulfate is a Nucleoside analog reverse transcriptase inhibitor (NRTI); guanosine analog used to treat HIV and AIDS. |
Features and Benefits: | This compound is a featured product for ADME Tox research. Click here ![]() ![]() |
Features and Benefits: | This compound was developed by GlaxoSmithKline ![]() ![]() |
General description: | Abacavir exhibits antiviral activity. It is associated with myocardial infarction and fatal hypersensitivity reaction (HSR). |
Packaging: | 10 mg in glass bottle |
Packaging: | 50 mg in poly bottle |
Symbol | ![]() ![]() |
Signal word | Warning |
Hazard statements | H317 - H319 - H341 - H351 - H361 |
Precautionary statements | P201 - P202 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313 |
Hazard Codes | Xn |
Risk Statements | 63-40 |
Safety Statements | 36/37 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |