Abacavir sulfate

SIGMA/SML0089 - ≥98% (HPLC)

Synonym: (1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol sulfate; ABC; Abacavir Hemisulfate

CAS Number: 188062-50-2
Empirical Formula (Hill Notation): C₁₄H₁₈N₆O · 0.5 H₂SO₄
Molecular Weight: 335.37
MDL Number: MFCD04112763
Linear Formula: C₁₄H₁₈N₆O · 0.5 H₂SO₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0089-10MG	10 mg	$123.00 1/EA	Add To Favorites
45-SML0089-50MG	50 mg	$472.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: SML0089-50MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to tan
form	powder
InChI	1S/2C14H18N6O.H2O4S/c215-14-18-12(17-9-2-3-9)11-13(19-14)20(7-16-11)10-4-1-8(5-10)6-21;1-5(2,3)4/h21,4,7-10,21H,2-3,5-6H2,(H3,15,17,18,19);(H2,1,2,3,4)/t2*8-,10+;/m11./s1
InChI key	WMHSRBZIJNQHKT-FFKFEZPRSA-N
optical activity	[α]/D -30 to -40°, c = 0.5 in methanol
originator	GlaxoSmithKline
Quality Level	100
SMILES string	OS(O)(=O)=O.Nc1nc(NC2CC2)c3ncn([C@@H]4C[C@H](CO)C=C4)c3n1.Nc5nc(NC6CC6)c7ncn([C@@H]8C[C@H](CO)C=C8)c7n5
solubility	H₂O: ≥17 mg/mL
storage temp.	2-8°C

Application:	Abacavir sulfate has been used as a compound to validate the P19C5 gastrulation in mouse. It has also been used to induces chromosomal double-strand breaks (DSBs) and kills adult T cell leukemia (ATL) cells.
Application:	Abacavir sulfate has been used in the cytotoxicity to test its tumour promoting activity U937 cells.
Biochem/physiol Actions:	Abacavir incorporated in the cells is converted to triphosphate containing guanine analog carbovir (CBV) and it favors the generation of higher double stranded breaks (DSBs).
Biochem/physiol Actions:	Abacavir sulfate is a Nucleoside analog reverse transcriptase inhibitor (NRTI); guanosine analog used to treat HIV and AIDS.
Biochem/physiol Actions:	Nucleoside analog reverse transcriptase inhibitor (NRTI); guanosine analog used to treat HIV and AIDS
Features and Benefits:	This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	This compound was developed by GlaxoSmithKline . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description:	Abacavir exhibits antiviral activity. It is associated with myocardial infarction and fatal hypersensitivity reaction (HSR).
Packaging:	10 mg in glass bottle
Packaging:	50 mg in poly bottle

Symbol	GHS07,GHS08
Signal word	Warning
Hazard statements	H317 - H319 - H341 - H351 - H361
Precautionary statements	P201 - P202 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
Hazard Codes	Xn
Risk Statements	63-40
Safety Statements	36/37
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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