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L-Dopa ethyl ester

SIGMA/SML0091 - ≥98% (HPLC)

Synonym: 3,4-Dihydroxy-L-phenylalanine ethyl ester; 3-Hydroxy-L-tyrosine ethyl ester; Etilevodopa; L-Dopa ethyl ester; L-Dopa-Et; Levodopa ethyl ester; O-Ethyl-DOPA; TV-1203

CAS Number: 37178-37-3
Empirical Formula (Hill Notation): C11H15NO4
Molecular Weight: 225.24
MDL Number: MFCD00871210
Linear Formula: C11H15NO4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0091-5MG 5 mg
 $145.00
1/EA		 Add To Favorites
45-SML0091-25MG 25 mg
 $580.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to tan
form powder
InChI 1S/C11H15NO4/c1-2-16-11(15)8(12)5-7-3-4-9(13)10(14)6-7/h3-4,6,8,13-14H,2,5,12H2,1H3/t8-/m0/s1
InChI key NULMGOSOSZBEQL-QMMMGPOBSA-N
optical activity [α]/D +15 to +19°, c = 1 in methanol ([α]/D)
Quality Level 100 
SMILES string CCOC(=O)[C@@H](N)Cc1ccc(O)c(O)c1
solubility H2O: ≥12 mg/mL at warmed to 60 °C
storage temp. 2-8°C
Application: L-Dopa ethyl ester has been used to study the protective effects of piperlongumine (PLG) on rotenone-induced Parkinson disease (PD).
Biochem/physiol Actions: L-Dopa ethyl ester (L-Dopa) is a dopamine replacement drug. It is used as a potent therapeutic for Parkinson disease (PD). L-Dopa has some long-term side effects, such as the deterioration of motor function.
Biochem/physiol Actions: L-Dopa ethyl ester is a prodrug of levodopa that has greater gastric solubility. The drug is rapidly hydrolyzed to levodopa by nonspecific esterases in the gastrointestinal tract. L-Dopa ethyl ester (etilevodopa)-carbidopa treatment was well tolerated but did not demonstrate better efficacy compared with standard levodopa-carbidopa treatment. L-Dopa ethyl ester should have a significant brain penetration following an administration by injection.
Biochem/physiol Actions: L-Dopa ethyl ester is prodrug of levodopa that has greater gastric solubility; antiparkinsonian agent
Features and Benefits: This compound is featured on the Dopamine and Norepinephrine Metabolism  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352108

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