Bikinin

SIGMA/SML0094 - ≥98% (HPLC)

Synonym: 4-((5-Bromo-2-pyridinyl)amino)-4-oxobutanoic acid; 4-[(5-Bromo-2-pyridinyl)amino]-4-oxo-butanoic acid; Abrasin

CAS Number: 188011-69-0
Empirical Formula (Hill Notation): C₉H₉BrN₂O₃
Molecular Weight: 273.08
MDL Number: MFCD00116442
Linear Formula: C₉H₉BrN₂O₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0094-5MG	5 mg	$101.00 1/EA	Add To Favorites
45-SML0094-25MG	25 mg	$413.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

application(s)	agriculture
assay	≥98% (HPLC)
color	white to tan
form	powder
InChI	1S/C9H9BrN2O3/c10-6-1-2-7(11-5-6)12-8(13)3-4-9(14)15/h1-2,5H,3-4H2,(H,14,15)(H,11,12,13)
InChI key	XFYYQDHEDOXWGA-UHFFFAOYSA-N
Quality Level	100
SMILES string	OC(=O)CCC(=O)Nc1ccc(Br)cn1
solubility	DMSO: ≥5 mg/mL
storage temp.	2-8°C

Application:	Bikinin has been used: • as a glycogen synthase kinase-3 (GSK3) inhibitor in Arabidopsis Col-0 seedlings to test its effect on gene expression • as a component of induction medium and as a GSK3 inhibitor to test its effect on mesophyll cells in Arabidopsis leaf discs or cotyledons • as a brassinosteroid agonist to test its effect on the leaf index of R. trichophyllus terrestrial leaves
Biochem/physiol Actions:	Bikinin is a strong activator of brassinosteroid (BR) signaling. It is an Arabidopsis GSK-3 Inhibitor, an Arabidopsis SHAGGY-related Kinase Inhibitor, and a GSK-3-like Kinase BIN2 Inhibitor. Bikinin directly inhibits BIN2 (group II GSK3s) by interfering with ATP binding. Bikinin is specific toward a subset of Arabidopsis GSK3 kinases including BIN2 and ASK α, γ, ε, ι, and θ.
Biochem/physiol Actions:	Inhibitor of Arabidopsis GSK-3, SHAGGY-related Kinase, and GSK-3-like Kinase BIN2
Packaging:	5, 25 mg in glass bottle

Hazard Codes	Xn
Risk Statements	22-36
Safety Statements	26
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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