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Conessine

SIGMA/SML0095 - ≥97% (HPLC)

Synonym: (3β)-N,N-dimethyl-con-5-enin-3-amine; Conessin; NSC 119994; Neriine; Roquessine; Wrightine

CAS Number: 546-06-5
Empirical Formula (Hill Notation): C24H40N2
Molecular Weight: 356.59
EC Number: 208-897-2
MDL Number: MFCD00016752
Linear Formula: C24H40N2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0095-10MG 10 mg
 $46.70
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45-SML0095-50MG 50 mg
 $168.00
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assay ≥97% (HPLC)
color white to tan
form powder
InChI 1S/C24H40N2/c1-16-20-8-9-22-19-7-6-17-14-18(25(3)4)10-12-23(17,2)21(19)11-13-24(20,22)15-26(16)5/h6,16,18-22H,7-15H2,1-5H3/t16-,18-,19+,20+,21-,22-,23-,24-/m0/s1
InChI key GPLGAQQQNWMVMM-MYAJQUOBSA-N
originator Abbott
Quality Level 100 
SMILES string C[C@H]1[C@H]2CC[C@H]3[C@@H]4CC=C5C[C@H](CC[C@]5(C)[C@H]4CC[C@]23CN1C)N(C)C
solubility ethanol: ≥2 mg/mL
storage temp. 2-8°C
Biochem/physiol Actions: Conessine is a plant steroid alkaloid that acts as a potent and specific antagonist of histamine H3 receptors (Ki = 5.37 and 24.5 nM for human and rat receptors, respectively). Conessine is 1860-fold selective for H3 over H4 and does not bind to H1 or H2 receptors. The molecule also binds to the human α2C4 adrenergic receptor (pKi = 7.98).
Biochem/physiol Actions: H3 receptor antagonist
Features and Benefits: This compound was developed by Abbott . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description: Conessine is a steroidal alkaloid. It has anti-malarial properties, thus, conessine has been used in treatment of malaria.
Packaging: 10, 50 mg in glass bottle
Purity ≥97% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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