Conessine

SIGMA/SML0095 - ≥97% (HPLC)

Synonym: (3β)-N,N-dimethyl-con-5-enin-3-amine; Conessin; NSC 119994; Neriine; Roquessine; Wrightine

CAS Number: 546-06-5
Empirical Formula (Hill Notation): C₂₄H₄₀N₂
Molecular Weight: 356.59
EC Number: 208-897-2
MDL Number: MFCD00016752
Linear Formula: C₂₄H₄₀N₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0095-10MG	10 mg	$53.40 1/EA	Add To Favorites
45-SML0095-50MG	50 mg	$193.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥97% (HPLC)
color	white to tan
form	powder
InChI	1S/C24H40N2/c1-16-20-8-9-22-19-7-6-17-14-18(25(3)4)10-12-23(17,2)21(19)11-13-24(20,22)15-26(16)5/h6,16,18-22H,7-15H2,1-5H3/t16-,18-,19+,20+,21-,22-,23-,24-/m0/s1
InChI key	GPLGAQQQNWMVMM-MYAJQUOBSA-N
originator	Abbott
Quality Level	100
SMILES string	C[C@H]1[C@H]2CC[C@H]3[C@@H]4CC=C5C[C@H](CC[C@]5(C)[C@H]4CC[C@]23CN1C)N(C)C
solubility	ethanol: ≥2 mg/mL
storage temp.	2-8°C

Biochem/physiol Actions:	Conessine is a plant steroid alkaloid that acts as a potent and specific antagonist of histamine H₃ receptors (Ki = 5.37 and 24.5 nM for human and rat receptors, respectively). Conessine is 1860-fold selective for H₃ over H₄ and does not bind to H₁ or H₂ receptors. The molecule also binds to the human α₂C₄ adrenergic receptor (pKi = 7.98).
Features and Benefits:	This compound was developed by Abbott . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description:	Conessine is a steroidal alkaloid. It has anti-malarial properties, thus, conessine has been used in treatment of malaria.
Packaging:	10, 50 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335
Precautionary statements	P302 + P352 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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