Nevirapine
SIGMA/SML0097
Synonym: 11-
CAS Number: 129618-40-2
Empirical Formula (Hill Notation): C15H14N4O
Molecular Weight: 266.30
MDL Number: MFCD00866928
Linear Formula: C15H14N4O
Product Type: Chemical
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML0097-50MG.
This image depicts SML0097-50MG.
| assay | ≥98% (HPLC) |
| color | white to tan |
| form | powder |
| InChI | 1S/C15H14N4O/c1-9-6-8-17- |
| InChI key | NQDJXKOVJZTUJA-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | CC1=CC=NC2=C1NC(C(C=CC=N3 |
| solubility | DMSO: ≥22 mg/mL |
| storage temp. | room temp |
| Application: | Nevirapine has been used as non-nucleoside reverse transcriptase inhibitor in in vitro porcine endogenous retrovirus replication, primary hepatocytes and bone marrow dendritic cells (BMDCs). |
| Biochem/physiol Actions: | Nevirapine interacts with glycine 190 residue of human immuno deficiency virus (HIV-2) reverse transcriptase. It is an antiretroviral drug which increases bile synthesis and activates electron transport chain. Use of nevirapine leads to liver toxicity and is associated with Nevirapine hypersensitivity syndrome. |
| Biochem/physiol Actions: | Nevirapine is an allosteric, non-nucleoside inhibitor of HIV reverse transcriptase (NNRTI). The Ki for inhibition of wild-type RT by Nevirapine is 200 nM. |
| Biochem/physiol Actions: | NNRTI (non-nucleoside reverse transcriptase inhibitor) of HIV-1 |
| Packaging: | 10, 50 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |