Synonym: 11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2′,3′-e][1,4]diazepin-6-one
CAS Number: 129618-40-2
Empirical Formula (Hill Notation): C15H14N4O
Molecular Weight: 266.30
MDL Number: MFCD00866928
Linear Formula: C15H14N4O
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to tan |
| form |
powder |
| InChI |
1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20) |
| InChI key |
NQDJXKOVJZTUJA-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
CC1=CC=NC2=C1NC(C(C=CC=N3)=C3N2C4CC4)=O |
| solubility |
DMSO: ≥22 mg/mL |
| storage temp. |
room temp |
| Application: |
Nevirapine has been used as non-nucleoside reverse transcriptase inhibitor in in vitro porcine endogenous retrovirus replication, primary hepatocytes and bone marrow dendritic cells (BMDCs). |
| Biochem/physiol Actions: |
Nevirapine interacts with glycine 190 residue of human immuno deficiency virus (HIV-2) reverse transcriptase. It is an antiretroviral drug which increases bile synthesis and activates electron transport chain. Use of nevirapine leads to liver toxicity and is associated with Nevirapine hypersensitivity syndrome. |
| Biochem/physiol Actions: |
Nevirapine is an allosteric, non-nucleoside inhibitor of HIV reverse transcriptase (NNRTI). The Ki for inhibition of wild-type RT by Nevirapine is 200 nM. |
| Biochem/physiol Actions: |
NNRTI (non-nucleoside reverse transcriptase inhibitor) of HIV-1 |
| Packaging: |
10, 50 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 2 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
room temp |
| UNSPSC |
12352200 |
