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Fluocinonide

SIGMA/SML0099 - ≥98% (HPLC)

Synonym: (6α,11β,16α)-21-(acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione; Lonide

CAS Number: 356-12-7
Empirical Formula (Hill Notation): C26H32F2O7
Molecular Weight: 494.52
EC Number: 206-597-6
MDL Number: MFCD00079302
Linear Formula: C26H32F2O7
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0099-10MG 10 mg
 $135.00
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45-SML0099-50MG 50 mg
 $542.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to tan
form powder
InChI 1S/C26H32F2O7/c1-13(29)33-12-20(32)26-21(34-22(2,3)35-26)10-15-16-9-18(27)17-8-14(30)6-7-23(17,4)25(16,28)19(31)11-24(15,26)5/h6-8,15-16,18-19,21,31H,9-12H2,1-5H3/t15-,16-,18-,19-,21+,23-,24-,25-,26+/m0/s1
InChI key WJOHZNCJWYWUJD-IUGZLZTKSA-N
optical activity [α]/D +75 to +90°, c = 1 in dichloromethane
Quality Level 100 
SMILES string CC(=O)OCC(=O)[C@@]12OC(C)(C)O[C@@H]1C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]23C
solubility DMSO: ≥19 mg/mL
storage temp. 2-8°C
Biochem/physiol Actions: Flucinonide is a fluorinated glucocorticid that is used as a topical anti-inflammatory agent. Recently, flucinonide and other fluorinated glucocorticolids were identified as smoothend agonists. Flucinonide induces expression of Gli-reporter luciferase in Shh-LIGHT2 cells.
Biochem/physiol Actions: Fluocinonide has been used to study its effect on T-cell proliferation.
Biochem/physiol Actions: Fluocinonide is shown to be effective in the treatment of atopic dermatitis and oral lichen planus (OLP).
Biochem/physiol Actions: very potent corticosteroid
Packaging: 10, 50 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 51111800

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