Fluocinonide

SIGMA/SML0099 - ≥98% (HPLC)

Synonym: (6α,11β,16α)-21-(acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione; Lonide

CAS Number: 356-12-7
Empirical Formula (Hill Notation): C₂₆H₃₂F₂O₇
Molecular Weight: 494.52
EC Number: 206-597-6
MDL Number: MFCD00079302
Linear Formula: C₂₆H₃₂F₂O₇
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0099-10MG	10 mg	$145.00 1/EA	Add To Favorites
45-SML0099-50MG	50 mg	$581.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to tan
form	powder
InChI	1S/C26H32F2O7/c1-13(29)33-12-20(32)26-21(34-22(2,3)35-26)10-15-16-9-18(27)17-8-14(30)6-7-23(17,4)25(16,28)19(31)11-24(15,26)5/h6-8,15-16,18-19,21,31H,9-12H2,1-5H3/t15-,16-,18-,19-,21+,23-,24-,25-,26+/m0/s1
InChI key	WJOHZNCJWYWUJD-IUGZLZTKSA-N
optical activity	[α]/D +75 to +90°, c = 1 in dichloromethane
Quality Level	100
SMILES string	CC(=O)OCC(=O)[C@@]12OC(C)(C)O[C@@H]1C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]23C
solubility	DMSO: ≥19 mg/mL
storage temp.	2-8°C

Biochem/physiol Actions:	Flucinonide is a fluorinated glucocorticid that is used as a topical anti-inflammatory agent. Recently, flucinonide and other fluorinated glucocorticolids were identified as smoothend agonists. Flucinonide induces expression of Gli-reporter luciferase in Shh-LIGHT2 cells.
Biochem/physiol Actions:	Fluocinonide has been used to study its effect on T-cell proliferation.
Biochem/physiol Actions:	Fluocinonide is shown to be effective in the treatment of atopic dermatitis and oral lichen planus (OLP).
Biochem/physiol Actions:	very potent corticosteroid
Packaging:	10, 50 mg in glass bottle

Symbol	GHS06,GHS08
Signal word	Danger
Hazard statements	H300 - H361
Precautionary statements	P201 - P301 + P310 + P330
Hazard Codes	T+
Risk Statements	63-28
Safety Statements	22-25-28-36/37/39-45
RIDADR	UN 2811 6.1 / PGII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	51111800

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