Synonym: (6α,11β,16α)-21-(acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione; Lonide
CAS Number: 356-12-7
Empirical Formula (Hill Notation): C26H32F2O7
Molecular Weight: 494.52
EC Number: 206-597-6
MDL Number: MFCD00079302
Linear Formula: C26H32F2O7
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to tan |
| form |
powder |
| InChI |
1S/C26H32F2O7/c1-13(29)33-12-20(32)26-21(34-22(2,3)35-26)10-15-16-9-18(27)17-8-14(30)6-7-23(17,4)25(16,28)19(31)11-24(15,26)5/h6-8,15-16,18-19,21,31H,9-12H2,1-5H3/t15-,16-,18-,19-,21+,23-,24-,25-,26+/m0/s1 |
| InChI key |
WJOHZNCJWYWUJD-IUGZLZTKSA-N |
| optical activity |
[α]/D +75 to +90°, c = 1 in dichloromethane |
| Quality Level |
100  |
| SMILES string |
CC(=O)OCC(=O)[C@@]12OC(C)(C)O[C@@H]1C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]23C |
| solubility |
DMSO: ≥19 mg/mL |
| storage temp. |
2-8°C |
| Biochem/physiol Actions: |
Flucinonide is a fluorinated glucocorticid that is used as a topical anti-inflammatory agent. Recently, flucinonide and other fluorinated glucocorticolids were identified as smoothend agonists. Flucinonide induces expression of Gli-reporter luciferase in Shh-LIGHT2 cells. |
| Biochem/physiol Actions: |
Fluocinonide has been used to study its effect on T-cell proliferation. |
| Biochem/physiol Actions: |
Fluocinonide is shown to be effective in the treatment of atopic dermatitis and oral lichen planus (OLP). |
| Packaging: |
10, 50 mg in glass bottle |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
51111800 |
GHS06,GHS08