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AMTB hydrate

SIGMA/SML0103 - ≥98% (HPLC)

Synonym: N-(3-aminopropyl)-2-[(3-methylphenyl)methoxy]-N-(2-thienylmethyl)-benzamide hydrochloride (1:1) hyclate

CAS Number: 926023-82-7 (anhydrous)
Empirical Formula (Hill Notation): C23H26N2O2S·HCl · xH2O
Molecular Weight: 430.99 (anhydrous basis)
Linear Formula: C23H26N2O2S·HCl · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0103-5MG 5 mg
 $135.00
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45-SML0103-25MG 25 mg
 $433.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to tan
form powder
InChI 1S/C23H26N2O2S.ClH.H2O/c1-18-8-2-3-9-19(18)17-27-22-12-5-4-11-21(22)23(26)25(14-7-13-24)16-20-10-6-15-28-20;;/h2-6,8-12,15H,7,13-14,16-17,24H2,1H3;1H;1H2
InChI key RTYVTAQFASBIDN-UHFFFAOYSA-N
Quality Level 100 
SMILES string O=C(C1=C(OCC2=C(C)C=CC=C2)C=CC=C1)N(CCCN)CC3=CC=CS3.Cl.O
solubility DMSO: ≥10 mg/mL
storage condition desiccated
storage temp. 2-8°C
Application: AMTB hydrate has been used as an inhibitor of transient receptor potential cation channel, subfamily melastatin, member 8 (TRPM8) in breast cancer cells and murine T cells.
Biochem/physiol Actions: AMTB is a 2-benzyloxy-benzoic acid amide derivative, which also inhibits voltage-gated sodium channels (Nav) and their isoforms.
Biochem/physiol Actions: AMTB is a TRPM8 ion channel blocker
Biochem/physiol Actions: AMTB is a TRPM8-selective antagonist with no cross reactivity to TRPV1 or 4. The pIC50 of icilin activation of TRPM8 is 6.23 i.v. administration of AMTB reduced the frequency of rhythmic contractions in volume-loaded bladder and inhibited blood pressure and visceromotor reflex responses to bladder distention.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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