AMTB hydrate
SIGMA/SML0103 - ≥98% (HPLC)
Synonym: N-
CAS Number: 926023-82-7 (anhydrous)
Empirical Formula (Hill Notation): C23H26N2O2S·HCl · xH2O
Molecular Weight: 430.99 (anhydrous basis)
Linear Formula: C23H26N2O2S·HCl · xH2O
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to tan |
form | powder |
InChI | 1S/C23H26N2O2S.ClH.H2O/c1 |
InChI key | RTYVTAQFASBIDN-UHFFFAOYSA |
Quality Level | 100 ![]() |
SMILES string | O=C(C1=C(OCC2=C(C)C=CC=C2 |
solubility | DMSO: ≥10 mg/mL |
storage condition | desiccated |
storage temp. | 2-8°C |
Application: | AMTB hydrate has been used as an inhibitor of transient receptor potential cation channel, subfamily melastatin, member 8 (TRPM8) in breast cancer cells and murine T cells. |
Biochem/physiol Actions: | AMTB is a 2-benzyloxy-benzoic acid amide derivative, which also inhibits voltage-gated sodium channels (Nav) and their isoforms. |
Biochem/physiol Actions: | AMTB is a TRPM8-selective antagonist with no cross reactivity to TRPV1 or 4. The pIC50 of icilin activation of TRPM8 is 6.23 i.v. administration of AMTB reduced the frequency of rhythmic contractions in volume-loaded bladder and inhibited blood pressure and visceromotor reflex responses to bladder distention. |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |