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Brequinar sodium salt hydrate

SIGMA/SML0113 - ≥97% (HPLC)

Synonym: 6-Fluoro-2-(2′-fluoro[1,1′-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid sodium hydrate; Biphenquinate sodium hydrate; DuP 785 hydrate; NSC 368390 hydrate

Empirical Formula (Hill Notation): C23H14F2NO2·Na · xH2O
Molecular Weight: 397.35 (anhydrous basis)
MDL Number: MFCD21363375
Linear Formula: C23H14F2NO2·Na · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0113-5MG 5 mg
 $129.00
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45-SML0113-25MG 25 mg
 $516.00
1/EA		 Add To Favorites

 

assay ≥97% (HPLC)
color off-white to brown
form powder
InChI 1S/C23H15F2NO2.Na.H2O/c1-13-21(23(27)28)18-12-16(24)10-11-20(18)26-22(13)15-8-6-14(7-9-15)17-4-2-3-5-19(17)25;;/h2-12H,1H3,(H,27,28);;1H2/q;+1;/p-1
InChI key IZXTTXFXRQGHKO-UHFFFAOYSA-M
Quality Level 100 
SMILES string O.[Na+].Cc1c(nc2ccc(F)cc2c1C([O-])=O)-c3ccc(cc3)-c4ccccc4F
solubility DMSO: ≥5 mg/mL
storage temp. 2-8°C
Application: Brequinar sodium salt hydrate has been used as a dihydroorotate dehydrogenase (DHODH) inhibitor:
• in drug response assays
• to induce depletion of cellular pyrimidine pools
• in cell proliferation assays
Application: Brequinar sodium salt hydrate may be used in cell signaling studies.
Biochem/physiol Actions: Brequinar exhibits anti-neoplastic activity against refractory solid tumors in human and mouse models. Continuous treatment is required for depletion of pyrimidine pools in the cancer cells and tumor inhibition.
Biochem/physiol Actions: Brequinar inhibits dihydroorotate dehydrogenase (DHODH), the fourth enzyme in the de novo pyrimidine biosynthesis pathway, preventing the synthesis of DNA and RNA. Brequinar has recently been found to have antiviral activity against a broad spectrum of viruses including flaviviruses (dengue virus, West Nile virus, yellow fever virus, and Powassan virus) and also a plus-strand RNA alphavirus (Western equine encephalitis virus) and a negative-strand RNA rhabdovirus (vesicular stomatitis virus).
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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