Pit-1

SIGMA/SML0122 - ≥98% (HPLC)

Synonym: N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]-benzamide

CAS Number: 53501-41-0
Empirical Formula (Hill Notation): C₁₄H₁₀ClN₃O₄S
Molecular Weight: 351.76
Linear Formula: C₁₄H₁₀ClN₃O₄S
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML0122-5MG	5 mg	$97.90 1/EA		Add To Favorites
45-SML0122-25MG	25 mg	$388.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to tan
form	powder
InChI	1S/C14H10ClN3O4S/c15-10-6-9(18(21)22)7-11(12(10)19)16-14(23)17-13(20)8-4-2-1-3-5-8/h1-7,19H,(H2,16,17,20,23)
InChI key	RIGXBXPAOGDDIG-UHFFFAOYSA-N
Quality Level	100
solubility	DMSO: ≥14 mg/mL
storage temp.	2-8°C

Application:	Pit-1 may be used in PIP3-mediated cell signaling studies.
Biochem/physiol Actions:	PIT-1 represents a new class of molecules referred to as PITenins, or PITs. PITs inhibit the binding of PIP3 to the PH domains of several target proteins, including Akt and PDK1, without affecting interactions against PIP2-selective PH domains. PIT-1 inhibits PI3K-PKD-1-Akt dependent phosphorylation in cell based assays, including the phosphorylation of Akt-1, 2 and 3.
Biochem/physiol Actions:	PIT-1 is a PIP3-PH domain antagonist
Biochem/physiol Actions:	Pit-1 is a small-molecule phosphatidylinositol-3,4,5-trisphosphate (PIP3) antagonist that binds and blocks the pleckstrin domain. It shows inhibitory effects on tumor angiogenesis and metastasis by interfering with the activation of Akt.
Features and Benefits:	This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07,GHS09
Signal word	Warning
Hazard statements	H302 - H400
Precautionary statements	P273 - P301 + P312 + P330
Hazard Codes	Xn,N
Risk Statements	22-50
Safety Statements	61
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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