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Rasagiline mesylate

SIGMA/SML0124 - ≥98% (HPLC)

Synonym: (1R)-2,3-Dihydro-N-2-propynl-1H-inden-1-amine methanesulfonate; N-Propargyl-1(R)-aminoindan methanesulfonate; TVP-1012

CAS Number: 161735-79-1
Empirical Formula (Hill Notation): C12H13N · CH4O3S
Molecular Weight: 267.34
MDL Number: MFCD08460604
Linear Formula: C12H13N · CH4O3S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0124-10MG 10 mg
 $118.00
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45-SML0124-50MG 50 mg
 $474.00
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assay ≥98% (HPLC)
color white to tan
form powder
InChI 1S/C12H13N.CH4O3S/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12;1-5(2,3)4/h1,3-6,12-13H,7-9H2;1H3,(H,2,3,4)/t12-;/m1./s1
InChI key JDBJJCWRXSVHOQ-UTONKHPSSA-N
optical activity [α]/D +15 to +28°, c = 0.6 mg/mL in H2O
Quality Level 100 
SMILES string CS(O)(=O)=O.C#CCN[C@@H]1CCc2ccccc12
solubility H2O: ≥20 mg/mL
storage condition desiccated
storage temp. 2-8°C
Application: Rasagiline mesylate has been used:
• to test its neuroprotective effects in retinitis pigmentosa (RP) by apoptosis regulator, Bax/Bcl-2 modulation
• as monoamine oxidase-B inhibitor in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced mouse model
• as an anti-parkinsonian agent to test its rescue functionality in 6-hydroxydopamine-lesioned zebrafish larvae towards bradykinetic and dyskinetic-like behavior
Application: Rasagiline mesylate may be used in MAO type B-mediated cell signaling studies.
Biochem/physiol Actions: Anti-Parkinson drug; MAO B Inhibitor; anti-apoptotic; neuroprotectant
Biochem/physiol Actions: Rasagiline mesylate is an effective therapeutic option in early stages of Parkinson′s disease. It improves the motor fluctuations in levodopa-treated patients and may be a useful adjunct to such patients. It has neuroprotective effects and increases the survival of dopaminergic neurons.
Biochem/physiol Actions: Rasagiline mesylate is an irreversible inhibitor of monoamine oxidase selective for MAO type B over type A by a factor of fourteen. It has anti-apoptotic and neuroprotectant activity and has been used as a treatment for Parkinson′s disease.
Features and Benefits: This compound is featured on the Dopamine and Norepinephrine Metabolism  and Histamine Synthesis and Metabolism  pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 10, 50 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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