Longdaysin
SIGMA/SML0127 - ≥98% (HPLC)
Synonym: 9-
Empirical Formula (Hill Notation): C16H16F3N5
Molecular Weight: 335.33
MDL Number: MFCD20527323
Linear Formula: C16H16F3N5
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to tan |
form | powder |
InChI | 1S/C16H16F3N5/c1-10(2)24- |
InChI key | REKSFCCYDQMSIN-UHFFFAOYSA |
Quality Level | 100 ![]() |
SMILES string | CC(C)N(C=N1)C2=C1C(NCC3=C |
solubility | DMSO: ≥15 mg/mL |
storage temp. | 2-8°C |
Application: | Longdaysin may be used to study cell signaling that regulate the circadian clock and behavior. |
Biochem/physiol Actions: | Longdaysin inhibits CK1, ERK2, and CDK7 kinases in low mM concentrations. The activity of longdaysin results in a lengthening of circadian periods in cell based and in vivo systems. Transgenic zebrafish harboring a per3-luc reporter gene displayed a 10 hour lengthening of circadian period when treated with longdaysin. Longdaysin reduces the phosphorylation of PER1 the regulator of molecular clock function and manipulates the circadian clock. |
Packaging: | 5, 25 mg in glass bottle |
Symbol | ![]() |
Signal word | Danger |
Hazard statements | H301 - H315 - H319 - H335 |
Precautionary statements | P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 |
Hazard Codes | T |
Risk Statements | 25-36/37/38 |
Safety Statements | 26-45 |
RIDADR | UN 2811 6.1 / PGIII |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |