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Longdaysin

SIGMA/SML0127 - ≥98% (HPLC)

Synonym: 9-isopropyl-N-(3-(trifluoromethyl)benzyl)-9H-purin-6-amine

CAS Number: 1353867-91-0
Empirical Formula (Hill Notation): C16H16F3N5
Molecular Weight: 335.33
MDL Number: MFCD20527323
Linear Formula: C16H16F3N5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0127-5MG 5 mg
 $133.00
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45-SML0127-25MG 25 mg
 $335.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to tan
form powder
InChI 1S/C16H16F3N5/c1-10(2)24-9-23-13-14(21-8-22-15(13)24)20-7-11-4-3-5-12(6-11)16(17,18)19/h3-6,8-10H,7H2,1-2H3,(H,20,21,22)
InChI key REKSFCCYDQMSIN-UHFFFAOYSA-N
Quality Level 100 
SMILES string CC(C)N(C=N1)C2=C1C(NCC3=CC(C(F)(F)F)=CC=C3)=NC=N2
solubility DMSO: ≥15 mg/mL
storage temp. 2-8°C
Application: Longdaysin may be used to study cell signaling that regulate the circadian clock and behavior.
Biochem/physiol Actions: Longdaysin inhibits CK1, ERK2, and CDK7 kinases in low mM concentrations. The activity of longdaysin results in a lengthening of circadian periods in cell based and in vivo systems. Transgenic zebrafish harboring a per3-luc reporter gene displayed a 10 hour lengthening of circadian period when treated with longdaysin. Longdaysin reduces the phosphorylation of PER1 the regulator of molecular clock function and manipulates the circadian clock.
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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