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Lanreotide acetate

SIGMA/SML0132 - ≥98% (HPLC)

Synonym: 3-(2-Naphthalenyl)-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-L-threoninamide cyclic (2→7)-disulfide acetate; Angiopeptin acetate; BIM-23014C

CAS Number: 127984-74-1
Empirical Formula (Hill Notation): C54H69N11O10S2 · xC2H4O2
Molecular Weight: 1096.32 (free base basis)
Linear Formula: C54H69N11O10S2 · xC2H4O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0132-5MG 5 mg
 $138.00
1/EA		 Add To Favorites
45-SML0132-25MG 25 mg
 $527.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to off-white
form powder
InChI 1S/C54H69N11O10S2.C2H4O2/c1-29(2)45-54(75)63-44(53(74)65-46(30(3)66)47(57)68)28-77-76-27-43(62-48(69)38(56)23-32-15-18-33-10-4-5-11-34(33)22-32)52(73)60-41(24-31-16-19-36(67)20-17-31)50(71)61-42(25-35-26-58-39-13-7-6-12-37(35)39)51(72)59-40(49(70)64-45)14-8-9-21-55;1-2(3)4/h4-7,10-13,15-20,22,26,29-30,38,40-46,58,66-67H,8-9,14,21,23-25,27-28,55-56H2,1-3H3,(H2,57,68)(H,59,72)(H,60,73)(H,61,71)(H,62,69)(H,63,75)(H,64,70)(H,65,74);1H3,(H,3,4)/t30-,38-,40+,41+,42-,43+,44?,45+,46+;/m1./s1
InChI key DEXPIBGCLCPUHE-HPDHVNDUSA-N
Quality Level 100 
shipped in wet ice
SMILES string CC(O)=O.CC(C)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O)NC(=O)[C@H](N)Cc5ccc6ccccc6c5
storage temp. −20°C
Application: Lanreotide acetate has been used as an inhibitor to test the plasticity of hydrogen sulfide modulation by growth hormone/thyroid hormone signaling in wild-type mice.
Biochem/physiol Actions: Lanreotide acetate is a somatostatin analog, a selective agonist for the SRIF-1 sst2 subtype of somatostatin receptor with a binding affinity of 0.8 nM for sst2 compared to 5.2 nM for sst5, 100 nM for sst3 and more than 1000 nM for the SRIF-2 subtypes, sst1 and sst4 receptors. It is used clinically in the management of acromegaly and symptoms caused by neuroendocrine tumors, and in recent studies can also inhibit tumor growth and has shown activity against non-endocrine tumors.
Packaging: 5, 25 mg in glass bottle
Symbol GHS08  GHS08
Signal word Warning
Hazard statements H361
Precautionary statements P281
Hazard Codes Xn
Risk Statements 63
Safety Statements 36/37
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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