Lanreotide acetate

SIGMA/SML0132 - ≥98% (HPLC)

Synonym: 3-(2-Naphthalenyl)-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-L-threoninamide cyclic (2→7)-disulfide acetate; Angiopeptin acetate; BIM-23014C

CAS Number: 127984-74-1
Empirical Formula (Hill Notation): C₅₄H₆₉N₁₁O₁₀S₂ · xC₂H₄O₂
Molecular Weight: 1096.32 (free base basis)
Linear Formula: C₅₄H₆₉N₁₁O₁₀S₂ · xC₂H₄O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0132-5MG	5 mg	$142.00 1/EA	Add To Favorites
45-SML0132-25MG	25 mg	$542.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to off-white
form	powder
InChI	1S/C54H69N11O10S2.C2H4O2/c1-29(2)45-54(75)63-44(53(74)65-46(30(3)66)47(57)68)28-77-76-27-43(62-48(69)38(56)23-32-15-18-33-10-4-5-11-34(33)22-32)52(73)60-41(24-31-16-19-36(67)20-17-31)50(71)61-42(25-35-26-58-39-13-7-6-12-37(35)39)51(72)59-40(49(70)64-45)14-8-9-21-55;1-2(3)4/h4-7,10-13,15-20,22,26,29-30,38,40-46,58,66-67H,8-9,14,21,23-25,27-28,55-56H2,1-3H3,(H2,57,68)(H,59,72)(H,60,73)(H,61,71)(H,62,69)(H,63,75)(H,64,70)(H,65,74);1H3,(H,3,4)/t30-,38-,40+,41+,42-,43+,44?,45+,46+;/m1./s1
InChI key	DEXPIBGCLCPUHE-HPDHVNDUSA-N
Quality Level	100
shipped in	wet ice
SMILES string	CC(O)=O.CC(C)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O)NC(=O)[C@H](N)Cc5ccc6ccccc6c5
storage temp.	−20°C

Application:	Lanreotide acetate has been used as an inhibitor to test the plasticity of hydrogen sulfide modulation by growth hormone/thyroid hormone signaling in wild-type mice.
Biochem/physiol Actions:	Lanreotide acetate is a somatostatin analog, a selective agonist for the SRIF-1 sst2 subtype of somatostatin receptor with a binding affinity of 0.8 nM for sst2 compared to 5.2 nM for sst5, 100 nM for sst3 and more than 1000 nM for the SRIF-2 subtypes, sst1 and sst4 receptors. It is used clinically in the management of acromegaly and symptoms caused by neuroendocrine tumors, and in recent studies can also inhibit tumor growth and has shown activity against non-endocrine tumors.
Biochem/physiol Actions:	Octapeptide somatostatin analog; sst2 somatostatin receptor agonist; Antineoplastic
Packaging:	5, 25 mg in glass bottle

Symbol	GHS08
Signal word	Warning
Hazard statements	H361
Precautionary statements	P281
Hazard Codes	Xn
Risk Statements	63
Safety Statements	36/37
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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