Synonym: 2-(Nicotinamide)-1,3,4-thiadiazole; N-(1,3,4-Thiadiazol-2-yl)-3-pyridinecarboxamide; N-(1,3,4-Thiadiazol-2-yl)pyridine-3-carboxamide; N-(1,3,4-Thiadiazolyl)-m-nicotinamide
CAS Number: 51987-99-6
Empirical Formula (Hill Notation): C8H6N4OS
Molecular Weight: 206.22
MDL Number: MFCD00708771
Linear Formula: C8H6N4OS
Product Type: Chemical
assay |
≥98% (HPLC) |
color |
white to tan |
form |
powder |
InChI |
1S/C8H6N4OS/c13-7(6-2-1-3-9-4-6)11-8-12-10-5-14-8/h1-5H,(H,11,12,13) |
InChI key |
AGEGZHOPKZFKBP-UHFFFAOYSA-N |
Quality Level |
100 ![External link](https://krackeler.com/images/sigma/ext-link.gif) |
SMILES string |
O=C(Nc1nncs1)c2cccnc2 |
solubility |
DMSO: ≥8 mg/mL |
storage temp. |
room temp |
Application: |
Beas2B human lung epithelial cells were treated with TGN-020 to study the effect on cigarette smoke extracts-induced CCN1 secretion. |
Biochem/physiol Actions: |
TGN-020 is an inhibitor of Aquaporin 4 (AQP4), the most abundant water channel in brain. Aquaporins (AQPs) are water channels required for maintaining fluid homeostasis and enabling water movement across barrier membranes, but can enhance pathological cellular volume changes and cause edema in injury states. Pretreatment with the AQP4 inhibitor TGN-020 significantly reduced the volume of brain edema associated with ischemic injury in a mouse model of focal cerebral ischemia. |
Packaging: |
5, 25 mg in glass bottle |
Symbol |
GHS07 |
Signal word |
Warning |
Hazard statements |
H302 |
Hazard Codes |
Xn |
Risk Statements |
22 |
RIDADR |
NONH for all modes of transport |
WGK Germany |
WGK 3 |
Flash Point(F) |
Not applicable |
Flash Point(C) |
Not applicable |
Purity |
≥98% (HPLC) |
Storage Temp. |
room temp |
UNSPSC |
12352200 |