Synonym: 5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-Indole hydrochloride; EMD-386088
CAS Number: 1171123-46-8
Empirical Formula (Hill Notation): C14H15ClN2 · HCl
Molecular Weight: 283.20
MDL Number: MFCD09038557
Linear Formula: C14H15ClN2 · HCl
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
yellow |
| form |
powder |
| InChI |
1S/C14H15ClN2.ClH/c1-9-14(10-4-6-16-7-5-10)12-8-11(15)2-3-13(12)17-9;/h2-4,8,16-17H,5-7H2,1H3;1H |
| InChI key |
WWSNDUWIZDYGIQ-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
Cl.Cc1[nH]c2ccc(Cl)cc2c1C3=CCNCC3 |
| solubility |
DMSO: ≥16 mg/mL |
| storage temp. |
2-8°C |
| Application: |
EMD386088 may be used to study 5-HT6-mediated cell signaling. |
| Biochem/physiol Actions: |
EMD-386088 is a potent serotonin 5-HT6-specific agonist. The IC50 for competition of LSD from 5-HT6 expressed in HEK cells is 7.4 nM, and the EC50 for stimulating cAMP production is 1 nM. EMD-386088 is inactive against other HT receptors except 5-HT3 (IC50 = 34 nM). |
| Biochem/physiol Actions: |
EMD386088 effectively reverses cholinergic and glutataminergic-induced deficits in cognitive functions. It may be a therapeutic option in improving associated learning in Alzheimer′s disease and schizophrenia. EMD386088 also exhibits anti-depressant and anxiolytic effects in rats. |
| Packaging: |
5, 25 mg in glass bottle |
| Symbol |
 GHS06 |
| Signal word |
Danger |
| Hazard statements |
H301 |
| Precautionary statements |
P301 + P310 |
| Hazard Codes |
Xn |
| Risk Statements |
22 |
| RIDADR |
UN 2811 6.1 / PGIII |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
