BV02
SIGMA/SML0140 - ≥98% (HPLC)
Synonym: 2-
CAS Number: 292870-53-2
Empirical Formula (Hill Notation): C20H15N3O5
Molecular Weight: 377.35
MDL Number: MFCD00356631
Linear Formula: C20H15N3O5
Product Type: Chemical
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This image depicts SML0140-5MG.
This image depicts SML0140-5MG.
| assay | ≥98% (HPLC) |
| color | white to off-white |
| description | The structure of BV02 differs slightly from the published form, but has been internally verified by Sigma-Aldrich quality control. |
| form | powder |
| InChI | 1S/C20H15N3O5/c1-11-16(19 |
| InChI key | ZFYSDSINNOLWGO-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | CN1N(c2ccccc2)C(=O)C(N3C( |
| solubility | DMSO: >5 mg/mL |
| storage temp. | room temp |
| Application: | BV02 has been used to study the effects of 14-3-3σ on P-glycoprotein and pregnane X receptor protein xpression. It has also been used as a control in studying BAP1 (BRCA1 (breast cancer gene)-associated protein 1) inducing cell death via interaction with 14-3-3 in neuroblastoma. |
| Application: | BV02, an inhibitor of the 14-3-3 scaffolding protein docking sites, may be used to study the roles and functions of 14-3-3 scaffolding proteins in signaling pathways involved in the cell cycle, and processes such as apoptosis, stress response, and malignant cell transformation. |
| Biochem/physiol Actions: | BV02 is an inhibitor of the 14-3-3 scaffolding proteins docking site. |
| Biochem/physiol Actions: | BV02 is an inhibitor of the 14-3-3 scaffolding proteins docking site. BV02 promotes the apoptotic death of cells expressing either wt Bcr-Abl construct or T315I mutation. It induces apoptosis by c-Abl release from 14-3-3? and re-location to nuclear compartment and at mitochondrial membranes. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS09 |
| Signal word | Warning |
| Hazard statements | H400 |
| Precautionary statements | P273 |
| Hazard Codes | N |
| Risk Statements | 50 |
| Safety Statements | 61 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |