Synonym: 2-(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-2,3-dihydro-1,3-dioxo-1H-isoindole-5-carboxylic acid
CAS Number: 292870-53-2
Empirical Formula (Hill Notation): C20H15N3O5
Molecular Weight: 377.35
MDL Number: MFCD00356631
Linear Formula: C20H15N3O5
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to off-white |
| description |
The structure of BV02 differs slightly from the published form, but has been internally verified by Sigma-Aldrich quality control. |
| form |
powder |
| InChI |
1S/C20H15N3O5/c1-11-16(19(26)23(21(11)2)13-6-4-3-5-7-13)22-17(24)14-9-8-12(20(27)28)10-15(14)18(22)25/h3-10H,1-2H3,(H,27,28) |
| InChI key |
ZFYSDSINNOLWGO-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
CN1N(c2ccccc2)C(=O)C(N3C(=O)c4ccc(cc4C3=O)C(O)=O)=C1C |
| solubility |
DMSO: >5 mg/mL |
| storage temp. |
room temp |
| Application: |
BV02 has been used to study the effects of 14-3-3σ on P-glycoprotein and pregnane X receptor protein xpression. It has also been used as a control in studying BAP1 (BRCA1 (breast cancer gene)-associated protein 1) inducing cell death via interaction with 14-3-3 in neuroblastoma. |
| Application: |
BV02, an inhibitor of the 14-3-3 scaffolding protein docking sites, may be used to study the roles and functions of 14-3-3 scaffolding proteins in signaling pathways involved in the cell cycle, and processes such as apoptosis, stress response, and malignant cell transformation. |
| Biochem/physiol Actions: |
BV02 is an inhibitor of the 14-3-3 scaffolding proteins docking site. BV02 promotes the apoptotic death of cells expressing either wt Bcr-Abl construct or T315I mutation. It induces apoptosis by c-Abl release from 14-3-3? and re-location to nuclear compartment and at mitochondrial membranes. |
| Packaging: |
5, 25 mg in glass bottle |
| Symbol |
 GHS09 |
| Signal word |
Warning |
| Hazard statements |
H400 |
| Precautionary statements |
P273 |
| Hazard Codes |
N |
| Risk Statements |
50 |
| Safety Statements |
61 |
| RIDADR |
UN 3077 9 / PGIII |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
room temp |
| UNSPSC |
12352200 |
