Trilostane
SIGMA/SML0141 - ≥98% (HPLC)
Synonym: (4α,5α,17β)-3,17-dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile
CAS Number: 13647-35-3
Empirical Formula (Hill Notation): C20H27NO3
Molecular Weight: 329.43
EC Number: 237-133-0
MDL Number: MFCD00199295
Linear Formula: C20H27NO3
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to tan |
form | powder |
InChI | 1S/C20H27NO3/c1-18-7-6-14 |
InChI key | KVJXBPDAXMEYOA-CXANFOAXSA |
Quality Level | 100 ![]() |
SMILES string | C[C@]12CC[C@H]3[C@@H](CC[ |
solubility | DMSO: ≥17 mg/mL |
storage temp. | 2-8°C |
Application: | Trilostane has been used to evaluate its capability to regulate the sex-dependent differences in the lipopolysaccharide (LPS)-induced inflammatory responses of astrocytes. |
Application: | Trilostane was used to inhibit the activity of 3β-hydroxysteroid dehydrogenase in mouse ovary. |
Biochem/physiol Actions: | Trilostane is an inhibitor of 3 β-hydroxysteroid dehydrogenase (3-β-HSD or delta 5-delta 4-isomerase), an essential enzyme for the biosynthesis of all classes of hormonal steroids. It has been used in the treatment of Cushing′s syndrome for stopping the production of cortisol, and is currently approved for dogs in the US, but is still a human drug in the UK and other countries. It is being investigated as a possible treatment for both breast cancer and prostate cancer to prevent the synthesis of estrogens and androgens from endogenous precursors. It has also been used to inhibit endogenous production of progesterone in research studies. |
Features and Benefits: | This compound is featured on the Nuclear Receptors (Steroids) ![]() ![]() |
General description: | Trilostane inhibits the production of adrenal steroids, such as cortisol and aldosterone. It is used to treat aldosteronism. |
Packaging: | 10, 50 mg in glass bottle |
Symbol | ![]() ![]() |
Signal word | Warning |
Hazard statements | H315 - H319 - H361 |
Precautionary statements | P201 - P302 + P352 - P305 + P351 + P338 - P308 + P313 |
Hazard Codes | Xi |
Risk Statements | 36/37/38-62 |
Safety Statements | 26-36/37 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 51111800 |