Valsartan

SIGMA/SML0142 - ≥98% (HPLC)

Synonym: N-(1-Oxopentyl)-N-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-L-valine

CAS Number: 137862-53-4
Empirical Formula (Hill Notation): C₂₄H₂₉N₅O₃
Molecular Weight: 435.52
MDL Number: MFCD00865840
Linear Formula: C₂₄H₂₉N₅O₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0142-10MG	10 mg	$107.00 1/EA	Add To Favorites
45-SML0142-50MG	50 mg	$431.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to tan
form	powder
InChI	1S/C24H29N5O3/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28)/t22-/m0/s1
InChI key	ACWBQPMHZXGDFX-QFIPXVFZSA-N
optical activity	[α]/D -55 to -70°, c = 1 in methanol
originator	Novartis
Quality Level	100
SMILES string	CCCCC(=O)N(Cc1ccc(cc1)-c2ccccc2-c3nnn[nH]3)[C@@H](C(C)C)C(O)=O
solubility	DMSO: ≥20 mg/mL
storage condition	desiccated
storage temp.	2-8°C

Application:	Mice were treated with valsartan to study the role of Ang II-dependent pathway in aldosterone-related effects.
Biochem/physiol Actions:	Valsartan is an Angiotensin II type 1 (AT1) receptor antagonist and anti-hypertensive. Valsartan renders protection against heart attack and stroke resulting from abrupt increase in blood pressure. Valsartan reduces myocardial-infarction-related complications in heart attack survivors.
Features and Benefits:	This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	This compound is featured on the Angiotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits:	This compound was developed by Novartis . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging:	10, 50 mg in glass bottle

Symbol	GHS07,GHS08
Signal word	Warning
Hazard statements	H336 - H361d
Precautionary statements	P201 - P308 + P313
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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