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Drospirenone

SIGMA/SML0147 - ≥98% (HPLC)

Synonym: 6β,7β:15β,16β -Dimethylene-3-oxo-17α-pregn-4-ene-21,17-carbolactone; Dihydrospirorenone

CAS Number: 67392-87-4
Empirical Formula (Hill Notation): C24H30O3
Molecular Weight: 366.49
EC Number: 266-679-2
MDL Number: MFCD00867350
Linear Formula: C24H30O3
Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-SML0147-10MG 10 mg
$97.90
1/EA
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45-SML0147-50MG 50 mg
$380.00
1/EA
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assay ≥98% (HPLC)
color white to tan
form powder
InChI 1S/C24H30O3/c1-22-6-3-12(25)9-17(22)13-10-14(13)20-16(22)4-7-23(2)21(20)15-11-18(15)24(23)8-5-19(26)27-24/h9,13-16,18,20-21H,3-8,10-11H2,1-2H3/t13-,14+,15-,16+,18+,20-,21+,22-,23+,24+/m1/s1
InChI key METQSPRSQINEEU-HXCATZOESA-N
optical activity [α]/D -180 to -195°, c = 1 in methanol
originator Bayer
Quality Level 100 
SMILES string C[C@]12CCC(=O)C=C1[C@@H]3C[C@@H]3[C@@H]4[C@@H]2CC[C@@]5(C)[C@H]4[C@@H]6C[C@@H]6[C@@]57CCC(=O)O7
solubility DMSO: ≥15
storage condition desiccated
storage temp. 2-8°C
Application: Drospirenone has been used as a progestogen agent in pond snail and fish.
Application: Drospirenone was tested for genotoxicity in rat and human hepatocytes.
Biochem/physiol Actions: Drospirenone is a fourth-generation progestin that has antimineralocorticoid, and antiandrogenic activity in addition to potent progestogenic activity. In two recent studies drospirenone appeared to double the risk of venous thromboembolism compared to levonorgestrel, although other studies found little added risk.
Features and Benefits: This compound is featured on the Nuclear Receptors (Steroids)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits: This compound was developed by Bayer . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 10, 50 mg in glass bottle
Symbol GHS08  GHS08
Signal word Danger
Hazard statements H360
Precautionary statements P201 - P308 + P313
Hazard Codes T
Risk Statements 60
Safety Statements 36/37
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 51111800

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