Tolcapone

SIGMA/SML0150 - ≥98% (HPLC)

Synonym: 3,4-Dihydroxy-4′-methyl-5-nitrobenzophenone; Ro 40-7592

CAS Number: 134308-13-7
Empirical Formula (Hill Notation): C₁₄H₁₁NO₅
Molecular Weight: 273.24
MDL Number: MFCD00866569
Linear Formula: C₁₄H₁₁NO₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML0150-10MG	10 mg	$77.00 1/EA		Add To Favorites
45-SML0150-50MG	50 mg	$329.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	yellow
form	powder
InChI	1S/C14H11NO5/c1-8-2-4-9(5-3-8)13(17)10-6-11(15(19)20)14(18)12(16)7-10/h2-7,16,18H,1H3
InChI key	MIQPIUSUKVNLNT-UHFFFAOYSA-N
originator	Roche
Quality Level	100
SMILES string	Cc1ccc(cc1)C(=O)c2cc(O)c(O)c(c2)[N+]([O-])=O
solubility	DMSO: ≥15 mg/mL
storage condition	desiccated
storage temp.	2-8°C

Application:	Tolcapone may be used in COMT-mediated cell signaling studies. Tolcapone has been used in methyltransferase assay in human embryonic kidney 293 cells.
Biochem/physiol Actions:	Inhibition of catechol-O-methyltransferase by tolcapone increases the half-life and bioavailabilty of levodopa. It therefore is an effective adjunctive therapy in patients with Parkinson′s disease with motor response fluctuations.
Biochem/physiol Actions:	Tolcapone is an orally active catechol-O-methyltransferase (COMT) inhibitor. It inhibits both central and peripheral COMT. Tolcapone crosses the blood-brain barrier, and has been used for L-DOPA adjunct therapy in the treatment of Parkinson′s Disease.
Features and Benefits:	This compound was developed by Roche . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging:	10, 50 mg in glass bottle

Symbol	GHS09
Signal word	Warning
Hazard statements	H400
Precautionary statements	P273
Hazard Codes	N
Risk Statements	50
Safety Statements	61
RIDADR	UN 3077 9 / PGIII
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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