AK-7
SIGMA/SML0152 - ≥98% (HPLC)
CAS Number: 420831-40-9
Empirical Formula (Hill Notation): C19H21BrN2O3S
Molecular Weight: 437.35
MDL Number: MFCD03140195
Linear Formula: C19H21BrN2O3S
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to tan |
form | powder |
InChI | 1S/C19H21BrN2O3S/c20-16-8 |
InChI key | IYAYHZZWYNXHEQ-UHFFFAOYSA |
Quality Level | 100 ![]() |
SMILES string | Brc1cccc(NC(=O)c2cccc(c2) |
solubility | DMSO: ≥15 mg/mL |
storage temp. | 2-8°C |
Application: | AK-7 has been used in cell culture and cell treatment. |
Biochem/physiol Actions: | AK-7 is a brain penetrant selective SIRT2 inhibitor. No inhibition of SIRT1 or SIRT3 detected. |
Biochem/physiol Actions: | In neurons, the sirtuin 2 inhibitor AK-7 is neuroprotective in vitro and decreases polyglutamine inclusions and cholesterol levels. In mice, treatment with brain-permeable SIRT2 inhibitor AK-7 led to improved motor function, extended survival and decreased brain atrophy. AK-7 decreases the polyglutamine aggregation in R6/2 brain. |
Biochem/physiol Actions: | Selective SIRT2 Inhibitor |
Biochem/physiol Actions: | Selective SIRT2 Inhibitor AK-7 is a brain penetrant selective SIRT2 inhibitor. No inhibition of SIRT1 or SIRT3 detected. |
General description: | AK-7 (3-(1-azepanylsulfonyl)-N-(3-bromphenyl) benzamide) is a cell- and brain-permeable, selective SIRT2 (sirtuin 2) inhibitor. |
Packaging: | 5, 25 mg in glass bottle |
Symbol | ![]() |
Signal word | Warning |
Hazard statements | H319 |
Precautionary statements | P305 + P351 + P338 |
Hazard Codes | Xi |
Risk Statements | 36 |
Safety Statements | 26 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |