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Reversan

SIGMA/SML0173 - ≥98% (HPLC)

Synonym: CBLC4H10; N-[3-(4-Morpholinyl)propyl]-5,7-diphenyl-pyrazolo[1,5-a]pyrimidine-3-carboxamide

CAS Number: 313397-13-6
Empirical Formula (Hill Notation): C26H27N5O2
Molecular Weight: 441.52
MDL Number: MFCD01528184
Linear Formula: C26H27N5O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0173-5MG 5 mg
 $133.00
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45-SML0173-25MG 25 mg
 $534.00
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assay ≥98% (HPLC)
color faintly yellow to yellow
form powder
InChI 1S/C26H27N5O2/c32-26(27-12-7-13-30-14-16-33-17-15-30)22-19-28-31-24(21-10-5-2-6-11-21)18-23(29-25(22)31)20-8-3-1-4-9-20/h1-6,8-11,18-19H,7,12-17H2,(H,27,32)
InChI key JTRXWCLQFAZHGP-UHFFFAOYSA-N
Quality Level 100 
SMILES string O=C(NCCCN1CCOCC1)c2cnn3c(cc(nc23)-c4ccccc4)-c5ccccc5
solubility DMSO: ≥8 mg/mL at ~60 °C
storage temp. 2-8°C
Application: Reversan may be used in cell signaling studies.
Biochem/physiol Actions: Nontoxic MRP1 function inhibitor; MRP1 and Pgp function inhibitor; multidrug transporter inhibitor
Biochem/physiol Actions: Reversan increases the efficacy of vincristine and etoposide and increases the sensitivity of murine models of neuroblastoma to conventional chemotherapy.
Biochem/physiol Actions: Reversan is a selective and nontoxic multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp) inhibitor.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12161501

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