Z36
SIGMA/SML0176 - ≥98% (HPLC)
Synonym: (Z)-5-Fluoro-1-(3′-dimethylamino)propyl-3-[(5′-methoxyindol-3-ylidene)methyl]-indolin-2-one; 1-
CAS Number: 1243148-19-7
Empirical Formula (Hill Notation): C23H24FN3O2
Molecular Weight: 393.45
Linear Formula: C23H24FN3O2
Product Type: Chemical
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML0176-5MG.
This image depicts SML0176-5MG.
| assay | ≥98% (HPLC) |
| color | light yellow to dark yellow |
| form | powder |
| InChI | 1S/C23H24FN3O2/c1-26(2)9- |
| InChI key | CQNOITUXWKRVMB-JAIQZWGSSA |
| Quality Level | 100  |
| SMILES string | COc1ccc2[nH]cc(C=C3/C(=O |
| solubility | DMSO: ≥15 mg/mL |
| storage temp. | −20°C |
| Application: | Z36 may be used to study cell signaling that results in autophagy. |
| Biochem/physiol Actions: | Bcl-XL inhibitor that induces autophagic cell death independent of apoptosis |
| Biochem/physiol Actions: | Z36 inhibits cell proliferation and induces death in HeLa cells. The cell death induced is via autophagy and autophagic flux. |
| Biochem/physiol Actions: | Z36 is a Bcl-XL inhibitor that induces autophagic cell death independent of apoptosis which distinguishes it from other Bcl-XL and Bcl-2 inhibitors that induce cancer cell death mainly through apoptosis. Z36 binds to the BH3 binding groove of BCL-XL where it is thought to induce autophagy through blocking the interaction between Bcl-XL/Bcl2 and Beclin 1. |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |