Z36
SIGMA/SML0176 - ≥98% (HPLC)
Synonym: (Z)-5-Fluoro-1-(3′-dimethylamino)propyl-3-[(5′-methoxyindol-3-ylidene)methyl]-indolin-2-one; 1-
CAS Number: 1243148-19-7
Empirical Formula (Hill Notation): C23H24FN3O2
Molecular Weight: 393.45
Linear Formula: C23H24FN3O2
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | light yellow to dark yellow |
| form | powder |
| InChI | 1S/C23H24FN3O2/c1-26(2)9- |
| InChI key | CQNOITUXWKRVMB-JAIQZWGSSA |
| Quality Level | 100  |
| SMILES string | COc1ccc2[nH]cc(C=C3/C(=O |
| solubility | DMSO: ≥15 mg/mL |
| storage temp. | −20°C |
| Application: | Z36 may be used to study cell signaling that results in autophagy. |
| Biochem/physiol Actions: | Z36 inhibits cell proliferation and induces death in HeLa cells. The cell death induced is via autophagy and autophagic flux. |
| Biochem/physiol Actions: | Z36 is a Bcl-XL inhibitor that induces autophagic cell death independent of apoptosis which distinguishes it from other Bcl-XL and Bcl-2 inhibitors that induce cancer cell death mainly through apoptosis. Z36 binds to the BH3 binding groove of BCL-XL where it is thought to induce autophagy through blocking the interaction between Bcl-XL/Bcl2 and Beclin 1. |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |