AUDA

SIGMA/SML0177 - ≥98% (HPLC)

Synonym: 12-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]-dodecanoic acid

CAS Number: 479413-70-2
Empirical Formula (Hill Notation): C₂₃H₄₀N₂O₃
Molecular Weight: 392.58
MDL Number: MFCD12912267
Linear Formula: C₂₃H₄₀N₂O₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML0177-10MG	10 mg	$108.00 1/EA		Add To Favorites
45-SML0177-50MG	50 mg	$419.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C23H40N2O3/c26-21(27)10-8-6-4-2-1-3-5-7-9-11-24-22(28)25-23-15-18-12-19(16-23)14-20(13-18)17-23/h18-20H,1-17H2,(H,26,27)(H2,24,25,28)/t18-,19+,20-,23-
InChI key	XLGSEOAVLVTJDH-UKBVAGSOSA-N
Quality Level	100
SMILES string	OC(=O)CCCCCCCCCCCNC(=O)NC12C[C@@H]3C[C@@H](C[C@@H](C3)C1)C2
solubility	DMSO: ≥10 mg/mL at warmed to 60 °C
storage temp.	−20°C

Application:	AUDA has been used in the inhibition of epoxide hydrolase in human macrophages and in inhibition of tumor necrosis factor α (TNF-α)- induced phosphorylation in human aortic smooth muscle cells.
Application:	AUDA may be used in soluble epoxide hydrolase-mediated cell signaling studies.
Biochem/physiol Actions:	AUDA is a potent inhibitor of soluble epoxide hydrolase
Biochem/physiol Actions:	Inhibition of soluble epoxide hydrolase by AUDA inhibits the metabolism of epoxyeicosatrienoic acids (EETs) and protects end-organs against the damaging effects of salt-sensitive hypertension. AUDA also renders protection against myocardial ischemia-reperfusion injury and cerebral ischemia.
Packaging:	10, 50 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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