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ARL-17477 dihydrochloride hydrate

SIGMA/SML0178 - ≥98% (HPLC)

Synonym: N-[4-[2-[[(3-chlorophenyl)methyl]amino]ethyl]phenyl]-2-thiophenecarboximidamide dihydrochloride hydrate

CAS Number: 866914-87-6 (anhydrous)
Empirical Formula (Hill Notation): C20H20ClN3S·2HCl · xH2O
Molecular Weight: 442.83 (anhydrous basis)
MDL Number: MFCD21608518
Linear Formula: C20H20ClN3S·2HCl · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0178-5MG 5 mg
 $153.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C20H20ClN3S.2ClH.H2O/c21-17-4-1-3-16(13-17)14-23-11-10-15-6-8-18(9-7-15)24-20(22)19-5-2-12-25-19;;;/h1-9,12-13,23H,10-11,14H2,(H2,22,24);2*1H;1H2
InChI key QOPATWWWZNTSQF-UHFFFAOYSA-N
originator AstraZeneca
Quality Level 100 
SMILES string O.Cl.Cl.Clc1cccc(CNCCc2ccc(NC(=N)c3cccs3)cc2)c1
solubility H2O: ≥5 mg/mL
storage condition desiccated
storage temp. 2-8°C
Application: ARL-17477 dihydrochloride hydrate may be used in cell signaling studies.
Biochem/physiol Actions: ARL-17477 dihydrochloride hydrate is a selective nNOS inhibitor
Biochem/physiol Actions: ARL-17477 is an nNOS specific inhibitor. The IC50 against rat nNOS is 35 nM and it has 100-fold selectivity over endothelial and inducible isoforms. ARL-17477 penetrates the brain, and reduces infarct size and reduces cerebral blood flow in several different rodent models of ischemic brain injury.
Features and Benefits: This compound was developed by AstraZeneca . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352202

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