S 17092
SIGMA/SML0181 - ≥98% (HPLC)
Synonym: (2S,3aS,7aS)
CAS Number: 176797-26-5
Empirical Formula (Hill Notation): C22H28N2O2S
Molecular Weight: 384.53
MDL Number: MFCD00948255
Linear Formula: C22H28N2O2S
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to tan |
form | powder |
InChI | 1S/C22H28N2O2S/c25-21(18- |
InChI key | NXSXRIHXEQSYEZ-KNJMJIDISA |
optical activity | [α]/D -140 to -170° in dichloromethane |
Quality Level | 100 ![]() |
SMILES string | O=C([C@@H]1C[C@@H]2CCCC[C |
solubility | DMSO: ≥10 mg/mL |
storage temp. | 2-8°C |
Application: | S 17092 may be used in prolyl endopeptidase-mediated cell signaling studies. |
Biochem/physiol Actions: | S-17092 is a potent, selective inhibitor of Prolyl oligopeptidase (POP), also known as prolyl endopeptidase (PEP or PE). Ki=1.5 nM. Nootropic. S-17092 inhibition of POP prevents breakdown and thus increases the activity of a number of neuropeptides, which is likely the basis for its nootropic activity. S 17092 has been shown to improve cognition. It improved cognitive task performance in chronic low dose MPTP-treated monkeys. S-17092 was recently used to inhibit the formation of AcSDKP from its precursor 43-mer thymosin ?4 (T?4). Ac-SDKP is involved in hemopoietic stem cell differentiation, is pro-angiogenic and antifibrogenic. |
Features and Benefits: | This compound is featured on the Neuropeptidases ![]() ![]() |
Packaging: | 5 mg in glass bottle |
Symbol | ![]() |
Signal word | Warning |
Hazard statements | H302 |
Hazard Codes | Xn |
Risk Statements | 22 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |