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S 17092

SIGMA/SML0181 - ≥98% (HPLC)

Synonym: (2S,3aS,7aS)-1-(((R,R)-2-Phenylcyclopropyl)carbonyl)-2-((thiazolidin-3-yl)carbonyl)octahydro-1H-indole; [(2S,3aS,7aS)-Octahydro-1-[[(1R,2R)-2-phenylcyclopropyl]carbonyl]-1H-indol-2-yl]-3-thiazolidinyl--methanone

CAS Number: 176797-26-5
Empirical Formula (Hill Notation): C22H28N2O2S
Molecular Weight: 384.53
MDL Number: MFCD00948255
Linear Formula: C22H28N2O2S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0181-5MG 5 mg
 $151.00
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assay ≥98% (HPLC)
color white to tan
form powder
InChI 1S/C22H28N2O2S/c25-21(18-13-17(18)15-6-2-1-3-7-15)24-19-9-5-4-8-16(19)12-20(24)22(26)23-10-11-27-14-23/h1-3,6-7,16-20H,4-5,8-14H2/t16-,17-,18+,19-,20-/m0/s1
InChI key NXSXRIHXEQSYEZ-KNJMJIDISA-N
optical activity [α]/D -140 to -170° in dichloromethane
Quality Level 100 
SMILES string O=C([C@@H]1C[C@@H]2CCCC[C@@H]2N1C(=O)[C@@H]3C[C@H]3c4ccccc4)N5CCSC5
solubility DMSO: ≥10 mg/mL
storage temp. 2-8°C
Application: S 17092 may be used in prolyl endopeptidase-mediated cell signaling studies.
Biochem/physiol Actions: Potent selective inhibitor of Prolyl oligopeptidase (POP), also known as prolyl endopeptidase (PEP or PE). Nootropic.
Biochem/physiol Actions: S-17092 is a potent, selective inhibitor of Prolyl oligopeptidase (POP), also known as prolyl endopeptidase (PEP or PE). Ki=1.5 nM. Nootropic.

S-17092 inhibition of POP prevents breakdown and thus increases the activity of a number of neuropeptides, which is likely the basis for its nootropic activity. S 17092 has been shown to improve cognition. It improved cognitive task performance in chronic low dose MPTP-treated monkeys. S-17092 was recently used to inhibit the formation of AcSDKP from its precursor 43-mer thymosin ?4 (T?4). Ac-SDKP is involved in hemopoietic stem cell differentiation, is pro-angiogenic and antifibrogenic.
Features and Benefits: This compound is featured on the Neuropeptidases  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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