Dp44mT

SIGMA/SML0186 - ≥98% (HPLC)

Synonym: 2-(Di-2-pyridinylmethylene)-N,N-dimethyl-hydrazinecarbothioamide; Di-2-pyridylketone-4,4,-dimethyl-3-thiosemicarbazone

CAS Number: 152095-12-0
Empirical Formula (Hill Notation): C₁₄H₁₅N₅S
Molecular Weight: 285.37
MDL Number: MFCD20527329
Linear Formula: C₁₄H₁₅N₅S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0186-5MG	5 mg	$87.60 1/EA	Add To Favorites
45-SML0186-25MG	25 mg	$371.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	yellow to orange
form	powder
InChI	1S/C14H15N5S/c1-19(2)14(20)18-17-13(11-7-3-5-9-15-11)12-8-4-6-10-16-12/h3-10H,1-2H3,(H,18,20)
InChI key	XOBIGRNRXCAMJQ-UHFFFAOYSA-N
originator	Bayer
Quality Level	100
SMILES string	CN(C)C(=S)NN=C(c1ccccn1)c2ccccn2
solubility	DMSO: ≥5 mg/mL
storage temp.	2-8°C

Application:	Dp44mT may be used in cell signaling studies.
Biochem/physiol Actions:	Cell-permeable iron chelator and top2a activity inhibitor
Biochem/physiol Actions:	Dp44mT (di-2-pyridylketone-4,4,-dimethyl-3-thiosemicarbazone) influences lysosome integrity through copper binding. It induces reactive oxygen species (ROS) generation by redox cycling of iron complex. Dp44mT exhibits anti cancer action by attenuating Ndrg-1 (N-myc downstream regulated 1), a metastasis suppressor protein. It also alters the cyclin family of proteins (A, B, D1, D2,D3 and cyclin-dependent kinase 2) known for cell-cycle regulation. Dp44mT is known to promote apoptosis in neuroepithelioma, melanoma and breast cancer.
Biochem/physiol Actions:	Dp44mT is an iron chelator that works as a selective anticancer agent. As other iron chelators it can serve as a therapeutic adjunct to doxorubicin treatment. Additionally Dm44mT possess DNA-damaging activity. It appears that that activity is mediated by top2a inhibition.
Disclaimer:	Material appears to be unstable in solution; make solutions immediately before use.
Features and Benefits:	This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	This compound was developed by Bayer . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging:	5, 25 mg in glass bottle

Symbol	GHS06
Signal word	Danger
Hazard statements	H301
Precautionary statements	P301 + P310
Hazard Codes	Xn
Risk Statements	22
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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