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CJ-13610

SIGMA/SML0187 - ≥98% (HPLC)

Synonym: Tetrahydro-4-[3-[[4-(2-methyl-1H-imidazol-1-yl)phenyl]thio]phenyl]-2H-pyran-4-carboxamide

CAS Number: 179420-17-8
Empirical Formula (Hill Notation): C22H23N3O2S
Molecular Weight: 393.50
MDL Number: MFCD00948114
Linear Formula: C22H23N3O2S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0187-5MG 5 mg
 $144.00
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45-SML0187-25MG 25 mg
 $557.00
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assay ≥98% (HPLC)
color white to tan
form powder
InChI 1S/C22H23N3O2S/c1-16-24-11-12-25(16)18-5-7-19(8-6-18)28-20-4-2-3-17(15-20)22(21(23)26)9-13-27-14-10-22/h2-8,11-12,15H,9-10,13-14H2,1H3,(H2,23,26)
InChI key VPTONMHDLLMOOV-UHFFFAOYSA-N
Quality Level 100 
SMILES string Cc1nccn1-c2ccc(Sc3cccc(c3)C4(CCOCC4)C(N)=O)cc2
solubility DMSO: ≥10 mg/mL
storage condition desiccated
storage temp. 2-8°C
Application: CJ-13610 may be used to study 5-lipoxygenase-mediated cell signaling.
Biochem/physiol Actions: CJ-13,610 is a potent inhbititor of 5-lipoxygenase (5-LO) activity (IC50 = 70 nM).
Biochem/physiol Actions: CJ-13610 inhibits the biosynthesis of leukotriene B4 and regulates the IL-6 mRNA expression in macrophages. It reduces fibrosis and necroinflammation of liver in carbon tetrachloride-treated mice.
Biochem/physiol Actions: Potent 5-lipoxygenase inhibitor
Features and Benefits: This compound is featured on the Leukotriene Receptors  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 51111800

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