Resiquimod
SIGMA/SML0196 - ≥98% (HPLC)
Synonym: 4-
CAS Number: 144875-48-9
Empirical Formula (Hill Notation): C17H22N4O2
Molecular Weight: 314.38
MDL Number: MFCD00937759
Linear Formula: C17H22N4O2
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: SML0196-10MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: SML0196-50MG
| assay | ≥98% (HPLC) |
| color | white to tan |
| form | powder |
| InChI | 1S/C17H22N4O2/c1-4-23-9-1 |
| InChI key | BXNMTOQRYBFHNZ-UHFFFAOYSA |
| Quality Level | 100  |
| shipped in | wet ice |
| SMILES string | CCOCc1nc2c(N)nc3ccccc3c2n |
| solubility | DMSO: 10 mg/mL, clear (warmed to 60 °C) |
| storage condition | desiccated |
| protect from light | |
| storage temp. | −20°C |
| Application: | Resiquimod has been used in the stimulation of bone marrow-derived dendritic cells (BMDCs) stimulation( and B cells. It has also been used as a ligand for toll-like receptors (TLR7) in malignant melanoma cell line B16F10. |
| Application: | Resiquimod may be used in immunological and cancer-related cell signaling studies. |
| Biochem/physiol Actions: | Resiquimod (R-848) is a potent synthetic agonist of TLR7/TLR8 that possesses antiviral and antitumoral activities. |
| Biochem/physiol Actions: | Resiquimod belongs to the class of imidazoquinolinamines compounds with immunomodulatory effects. Resiquimod increases the levels of cytokines such as TNF-α, IL-6 and IFN-α. |
| Biochem/physiol Actions: | Resiquimod is 314.4 Da molecule which elicits immune function during visceral infection with L. infantum Sp. It mediates the trafficking of granulocytes, macrophages, leukocytes and dendritic cells. It is a recommended topical drug for treating skin tumors like actinic keratosis (AK) and superficial basal cell carcinoma. |
| Features and Benefits: | This compound is featured on the Cytokine Receptors (Interleukin-1 Receptor/TIR Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 10, 50 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |