4E1RCat
SIGMA/SML0197 - ≥97% (HPLC)
Synonym: 4-
Empirical Formula (Hill Notation): C28H18N2O6
Molecular Weight: 478.45
MDL Number: MFCD01931282
Linear Formula: C28H18N2O6
Product Type: Chemical
assay | ≥97% (HPLC) |
color | faint brown to dark brown-red |
form | powder |
InChI | 1S/C28H18N2O6/c31-27-21(1 |
InChI key | BBQRBOIMSKMFFO-LTGZKZEYSA |
originator | Merck & Co., Inc., Kenilworth, NJ, U.S. |
Quality Level | 100 ![]() |
SMILES string | OC(=O)c1ccc(cc1)N2C(=O)C |
solubility | DMSO: ≥5 mg/mL |
storage temp. | 2-8°C |
Application: | 4E1RCat was used to inhibit new protein synthesis in transformed primary chicken embryo fibroblasts. |
Biochem/physiol Actions: | 4E1RCat ilnhibits the eIF4F translation initiation complex by binding to IF4E b and inhibiting the interaction between IF4E:eIF4G (IC50 = 3.2 μM). In in vitro translation experiments using MDA-MB-231 cells, 4E1RCat dose dependently inhibited cap-dependent translation, led to a decrease in polysome and 80S ribosomal subunits and reduced levels of the eIF4F-dependant proteins Mcl-1 and c-Myc. |
Features and Benefits: | This compound is a featured product for Gene Regulation research. Click here ![]() ![]() |
Features and Benefits: | This compound is featured on the MAPKAPs ![]() ![]() |
Features and Benefits: | This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S. ![]() ![]() |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥97% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |