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4E1RCat

SIGMA/SML0197 - ≥97% (HPLC)

Synonym: 4-[(3E)-3-[[5-(4-nitrophenyl)furan-2-yl]methylidene]-2-oxo-5-phenylpyrrol-1-yl]benzoic acid

CAS Number: 328998-25-0
Empirical Formula (Hill Notation): C28H18N2O6
Molecular Weight: 478.45
MDL Number: MFCD01931282
Linear Formula: C28H18N2O6
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0197-5MG 5 mg
 $174.00
1/EA		 Add To Favorites
45-SML0197-25MG 25 mg
 $696.00
1/EA		 Add To Favorites

 

assay ≥97% (HPLC)
color faint brown to dark brown-red
form powder
InChI 1S/C28H18N2O6/c31-27-21(16-24-14-15-26(36-24)19-6-12-23(13-7-19)30(34)35)17-25(18-4-2-1-3-5-18)29(27)22-10-8-20(9-11-22)28(32)33/h1-17H,(H,32,33)/b21-16+
InChI key BBQRBOIMSKMFFO-LTGZKZEYSA-N
originator Merck & Co., Inc., Kenilworth, NJ, U.S.
Quality Level 100 
SMILES string OC(=O)c1ccc(cc1)N2C(=O)C(=Cc3ccc(o3)-c4ccc(cc4)[N+]([O-])=O)C=C2c5ccccc5
solubility DMSO: ≥5 mg/mL
storage temp. 2-8°C
Application: 4E1RCat was used to inhibit new protein synthesis in transformed primary chicken embryo fibroblasts.
Biochem/physiol Actions: 4E1RCat ilnhibits the eIF4F translation initiation complex by binding to IF4E b and inhibiting the interaction between IF4E:eIF4G (IC50 = 3.2 μM). In in vitro translation experiments using MDA-MB-231 cells, 4E1RCat dose dependently inhibited cap-dependent translation, led to a decrease in polysome and 80S ribosomal subunits and reduced levels of the eIF4F-dependant proteins Mcl-1 and c-Myc.
Biochem/physiol Actions: 4E1RCat is an inhibitor of translation initiation complex eIF4F
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the MAPKAPs  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits: This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S. . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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