Fenoldopam mesylate
SIGMA/SML0198 - ≥98% (HPLC)
Synonym: Fenoldopam methanesulfonate
CAS Number: 67227-57-0
Empirical Formula (Hill Notation): C16H16ClNO3 · CH4O3S
Molecular Weight: 401.86
EC Number: 266-612-7
MDL Number: MFCD04112986
Linear Formula: C16H16ClNO3 · CH4O3S
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to tan |
| form | powder |
| InChI | 1S/C16H16ClNO3.CH4O3S/c17 |
| InChI key | CVKUMNRCIJMVAR-UHFFFAOYSA |
| mp | 271 °C (lit.) |
| Quality Level | 100  |
| SMILES string | CS(O)(=O)=O.Oc1ccc(cc1)C2 |
| solubility | DMSO: ≥15 mg/mL at ~60 °C |
| storage condition | desiccated |
| storage temp. | room temp |
| Application: | Fenoldopam mesylate may be used to study dopamine D1-mediated cell signaling. |
| Biochem/physiol Actions: | Fenoldopam mesylate (FM) is considered as an effective therapeutic agent to prevent the onset of postoperative AKI (PO-AKI). In healthy cats, FM can stimulate diuresis and be well-tolerated. This benzazepine-derivative is regional specific and does not cause cerebral vasodilation. |
| Biochem/physiol Actions: | Fenoldopam mesylate is a selective dopamine D1 receptor agonist used as an antihypertensive agent. It is an agonist for D1-like dopamine receptors and binds with moderate affinity to α2-adrenoceptors. It has no significant affinity for D2-like receptors, α1 and α-adrenoceptors, 5HT1 and 5HT2 receptors, or muscarinic receptors. Fenoldopam mesylate causes peripheral vasodilation by stimulating dopamine-1receptors and α2-adrenoceptors, increasing renal blood flow. |
| Features and Benefits: | This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 10, 50 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 - H317 - H319 |
| Precautionary statements | P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | Xn |
| Risk Statements | 22-36-42/43 |
| Safety Statements | 22-26-36/37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| mp | 271 °C (lit.) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |