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DPH

SIGMA/SML0202 - ≥98% (HPLC)

Synonym: 5-(1,3-diaryl-1H-pyrazol-4-yl)hydantoin; 5-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]-2,4-imidazolidinedione

CAS Number: 484049-04-9
Empirical Formula (Hill Notation): C18H13FN4O2
Molecular Weight: 336.32
MDL Number: MFCD03268950
Linear Formula: C18H13FN4O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0202-5MG 5 mg
 $114.00
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45-SML0202-25MG 25 mg
 $458.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to tan
form powder
InChI 1S/C18H13FN4O2/c19-12-8-6-11(7-9-12)15-14(16-17(24)21-18(25)20-16)10-23(22-15)13-4-2-1-3-5-13/h1-10,16H,(H2,20,21,24,25)
InChI key MPQWYPLPWGUMJE-UHFFFAOYSA-N
Quality Level 100 
SMILES string Fc1ccc(cc1)-c2nn(cc2C3NC(=O)NC3=O)-c4ccccc4
solubility DMSO: ≥10 mg/mL
storage temp. 2-8°C
Application: DPH may be used in c-Abl tyrosine kinase-mediated cell signaling studies.
Biochem/physiol Actions: DPH binds and alters the conformation of the myristoyl binding site of c-Abl tyrosine kinase. It exhibits potent enzymatic and cellular activity that stimulates the activation of c-Abl.
Biochem/physiol Actions: DPH is a potent cell permeable c-Abl activator. DPH binds to the myristoyl binding site and leads to activation of c-Abl kinase activity. The compound stimulates the phosphorylation of c-Abl and its downstream substrate Crk.
Features and Benefits: This compound is a featured product for Kinase Phosphatase Biology research. Click here  to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the Abl  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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