iCRT14

SIGMA/SML0203 - ≥98% (HPLC)

Synonym: 5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedione

CAS Number: 677331-12-3
Empirical Formula (Hill Notation): C₂₁H₁₇N₃O₂S
Molecular Weight: 375.44
MDL Number: MFCD04366833
Linear Formula: C₂₁H₁₇N₃O₂S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0203-5MG	5 mg	$119.00 1/EA	Add To Favorites
45-SML0203-25MG	25 mg	$472.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	yellow to orange
form	powder
InChI	1S/C21H17N3O2S/c1-14-11-16(15(2)23(14)18-9-6-10-22-13-18)12-19-20(25)24(21(26)27-19)17-7-4-3-5-8-17/h3-13H,1-2H3/b19-12-
InChI key	NCSHZXNGQYSKLR-UNOMPAQXSA-N
Quality Level	100
SMILES string	Cc1cc(C=C2/SC(=O)N(c3ccccc3)C2=O)c(C)n1-c4cccnc4
solubility	DMSO: ≥10 mg/mL
storage temp.	2-8°C

Application:	iCRT14 may be used in Wnt /β-catenin-mediated cell signaling studies.
Biochem/physiol Actions:	iCRT14 belongs to the thiazolidinedione class of β-catenin-responsive transcription inhibitors. It decreases the levels of Dishevelled protein and modulates the binding of T-cell factor (TCF) to DNA. It results in consistent decrease in reduction of cell proliferation and tumor growth in colon cancer cells.
Biochem/physiol Actions:	iCRT14 is a Wnt / β-catenin pathway inhibitor. It is a potent inhibitor of Catenin Responsive Transcription (CRT) reporter genes, as well as endogenous gene targets. iCRT14 also disrupts β-catenin-TCF4 interaction in a dose dependent manner, and causes G₀/G₁ arrest in colon tumor lines.
Biochem/physiol Actions:	Wnt / beta-catenin pathway inhibitor
Packaging:	5, 25 mg in glass bottle

Hazard Codes	Xn
Risk Statements	22
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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