iCRT14
SIGMA/SML0203 - ≥98% (HPLC)
Synonym: 5-
CAS Number: 677331-12-3
Empirical Formula (Hill Notation): C21H17N3O2S
Molecular Weight: 375.44
MDL Number: MFCD04366833
Linear Formula: C21H17N3O2S
Product Type: Chemical
assay | ≥98% (HPLC) |
color | yellow to orange |
form | powder |
InChI | 1S/C21H17N3O2S/c1-14-11-1 |
InChI key | NCSHZXNGQYSKLR-UNOMPAQXSA |
Quality Level | 100 ![]() |
SMILES string | Cc1cc(C=C2/SC(=O)N(c3ccc |
solubility | DMSO: ≥10 mg/mL |
storage temp. | 2-8°C |
Application: | iCRT14 may be used in Wnt /β-catenin-mediated cell signaling studies. |
Biochem/physiol Actions: | iCRT14 belongs to the thiazolidinedione class of β-catenin-responsive transcription inhibitors. It decreases the levels of Dishevelled protein and modulates the binding of T-cell factor (TCF) to DNA. It results in consistent decrease in reduction of cell proliferation and tumor growth in colon cancer cells. |
Biochem/physiol Actions: | iCRT14 is a Wnt / β-catenin pathway inhibitor. It is a potent inhibitor of Catenin Responsive Transcription (CRT) reporter genes, as well as endogenous gene targets. iCRT14 also disrupts β-catenin-TCF4 interaction in a dose dependent manner, and causes G0/G1 arrest in colon tumor lines. |
Packaging: | 5, 25 mg in glass bottle |
Hazard Codes | Xn |
Risk Statements | 22 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |